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来自(罗尔夫)梅里尔的生物活性天然产物的药理学概述

Pharmacological Overview of Bioactive Natural Products from (Lour.) Merr.

作者信息

Bose Ponkti Addrita, Sohag Md Mehadi Hasan, Rabbee Muhammad Fazle, Zamee Tareque Muzahid, Kona Jab-Un-Nisha, Elora Bonhi, Zaki Randa Mohammed, Islam Kamrul, Baek Kwang-Hyun

机构信息

Department of Genetic Engineering and Biotechnology, Jagannath University, Dhaka 1100, Bangladesh.

Biotechnology Research Initiative for Sustainable Development, Dhaka 1219, Bangladesh.

出版信息

Plants (Basel). 2025 Sep 1;14(17):2714. doi: 10.3390/plants14172714.

DOI:10.3390/plants14172714
PMID:40941879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12430178/
Abstract

is a commonly adopted medicinal plant native to the tropical regions of East and Southeast Asia and is well recognized for its significant therapeutic potential. Traditionally used in herbal medicine, it has been employed to manage various conditions, including hypertension, diabetes, renal disorders, constipation, and inflammation. Its leaves are particularly rich in flavonoids-such as astragalin, kaempferol, quercetin, myricetin, and rutin-which are associated with anti-glycaemic, anticancer, antihypertensive, antimicrobial, and antioxidant activities. These bioactive constituents form the basis of the broad pharmacological profile of the plant. Emerging studies also suggest a potential role for in the management of infertility, further broadening its therapeutic scope. This review provides a concise overview of its phytochemical constituents, taxonomic classification, and current pharmacological evidence, highlighting its potential as a valuable candidate for novel drug development.

摘要

是一种常见的药用植物,原产于东亚和东南亚的热带地区,因其具有显著的治疗潜力而广为人知。传统上用于草药医学,它被用于治疗各种病症,包括高血压、糖尿病、肾脏疾病、便秘和炎症。其叶子特别富含黄酮类化合物,如紫云英苷、山奈酚、槲皮素、杨梅素和芦丁,这些化合物具有抗血糖、抗癌、抗高血压、抗菌和抗氧化活性。这些生物活性成分构成了该植物广泛药理特性的基础。新兴研究还表明其在不孕症管理中可能发挥作用,进一步拓宽了其治疗范围。本综述简要概述了其植物化学成分、分类学分类和当前的药理证据,突出了其作为新型药物开发有价值候选物的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77df/12430178/2a7ac7040aea/plants-14-02714-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77df/12430178/1002c7d5f636/plants-14-02714-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77df/12430178/693b5cf3b70f/plants-14-02714-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77df/12430178/2a7ac7040aea/plants-14-02714-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77df/12430178/1002c7d5f636/plants-14-02714-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77df/12430178/693b5cf3b70f/plants-14-02714-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77df/12430178/2a7ac7040aea/plants-14-02714-g003.jpg

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本文引用的文献

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Therapeutic applications of quercetin-metallic complexes: a review.槲皮素-金属配合物的治疗应用:综述
Biometals. 2025 May 22. doi: 10.1007/s10534-025-00696-4.
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Decoding tumor angiogenesis: pathways, mechanisms, and future directions in anti-cancer strategies.解码肿瘤血管生成:抗癌策略中的途径、机制及未来方向
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Erratum to: Diabetes, obesity, and cardiovascular disease-what is the impact of lifestyle modification?《糖尿病、肥胖症与心血管疾病——生活方式改变有何影响?》勘误
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Anti-inflammatory potential of quercetin: From chemistry and mechanistic insight to nanoformulations.槲皮素的抗炎潜力:从化学和作用机制洞察到纳米制剂
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Quercetin liposomes conjugated with hyaluronidase: An efficient drug delivery system to block pancreatic cancer.与透明质酸酶偶联的槲皮素脂质体:一种用于阻断胰腺癌的高效药物递送系统。
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Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation.黄芪苷通过维持血脑屏障完整性和抑制神经炎症来减轻脂多糖诱导的小鼠抑郁样行为。
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Gynura procumbens leaf extract-loaded self-microemulsifying drug delivery system offers enhanced protective effects in the hepatorenal organs of the experimental rats.平卧菊三七叶提取物自微乳化药物递送系统对实验大鼠的肝肾器官具有增强的保护作用。
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Astragalin Exerted Hypoglycemic Effect by Both Inhibiting α-Glucosidase and Modulating AMPK Signaling Pathway.黄芪苷通过抑制α-葡萄糖苷酶和调节AMPK信号通路发挥降糖作用。
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Oral administration of ethanol extract from stems corrects kidney injury and renal anemia in chronic kidney disease.口服茎部乙醇提取物可纠正慢性肾病中的肾损伤和肾性贫血。
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