现代埃施魏勒-克拉克甲基化反应综述。

Review of Modern Eschweiler-Clarke Methylation Reaction.

作者信息

Zhou Xiaoli, Ni Xue, Wu Xianfu, Yin Lihui

机构信息

National Institutes for Food and Drug Control, Beijing 102629, China.

出版信息

Molecules. 2025 Aug 27;30(17):3504. doi: 10.3390/molecules30173504.

DOI:10.3390/molecules30173504

PMID:40942032

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12430128/

Abstract

This paper reviews a substantial amount of research related to the Eschweiler-Clarke methylation reaction, summarizing its mechanism, development, and applications, to present the chemical essence and history of this reaction and its importance and application in modern synthetic chemistry. In particular, this review focuses on advances regarding the Eschweiler-Clarke methylation reaction since 2000. This work will provide researchers with a comprehensive and in-depth perspective of the Eschweiler-Clarke reaction, as well as guidance and inspiration for future research and application.

摘要

本文综述了大量与埃施魏勒-克拉克甲基化反应相关的研究，总结了其反应机理、发展历程及应用，以展现该反应的化学本质、历史以及在现代合成化学中的重要性和应用。特别地，本综述聚焦于2000年以来埃施魏勒-克拉克甲基化反应的进展。这项工作将为研究人员提供关于埃施魏勒-克拉克反应全面而深入的视角，以及对未来研究和应用的指导与启发。