Stanescu Cristina, Chiscop Iulia, Mihalache Daniela, Boev Monica, Tamas Camelia, Stoleriu Gabriela
Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University, 35 Alexandru Ioan Cuza Street, 800216 Galati, Romania.
Clinical Surgical Department, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University, 800008 Galati, Romania.
Molecules. 2025 Aug 31;30(17):3568. doi: 10.3390/molecules30173568.
Micronutrients and nutraceuticals play crucial roles in wound healing and tissue regeneration, supporting various physiological processes. This review aims to synthesize and evaluate the functions of various micronutrients and nutraceuticals, emphasizing the synergistic interactions among different nutrients that facilitate wound healing processes. A thorough literature review was performed using electronic databases, including PubMed, Scopus, Web of Science, Embase, Google Scholar, and Cochrane Library, to identify molecular studies, animal models, randomized controlled trials, and observational human studies published up to January 2000. Two independent reviewers screened the articles, extracted data, and evaluated the Risk of Bias using the Risk of Bias 2 (RoB 2) tool for the 190 studies that met the inclusion criteria. Evidence suggests that bioactive compounds found in functional foods and dietary supplements can help prevent chronic conditions and promote wellness beyond basic nutrition. Vitamins A, C, and E, as well as minerals such as zinc, selenium, and iron, are essential for cell proliferation and the formation of new tissues. Additionally, nutraceuticals, including omega-3 fatty acids, glutamine, arginine, and polyphenols, exhibit anti-inflammatory and antioxidant properties, which promote healing and reduce the risk of infection. Probiotics and other bioactive compounds in nutraceuticals contribute to maintaining the balance of microbiota, reducing inflammation, and stimulating cell regeneration. Significant variability was noted in study design, sample size, intervention dosage, and outcome measures. This evidence underscores the necessity for further well-designed clinical trials to determine the optimal dosages and combinations for specific wound types across diverse patient populations. This systematic review was prospectively registered in PROSPERO (ID: 1072091).
微量营养素和营养保健品在伤口愈合和组织再生中发挥着关键作用，支持着各种生理过程。本综述旨在综合和评估各种微量营养素和营养保健品的功能，强调不同营养素之间的协同相互作用，这些相互作用促进了伤口愈合过程。使用包括PubMed、Scopus、Web of Science、Embase、谷歌学术和Cochrane图书馆在内的电子数据库进行了全面的文献综述，以识别截至2000年1月发表的分子研究、动物模型、随机对照试验和观察性人体研究。两名独立评审员筛选了文章，提取了数据，并使用偏倚风险2（RoB 2）工具对符合纳入标准的190项研究评估了偏倚风险。有证据表明，功能性食品和膳食补充剂中发现的生物活性化合物有助于预防慢性病，并在基本营养之外促进健康。维生素A、C和E，以及锌、硒和铁等矿物质对细胞增殖和新组织的形成至关重要。此外，营养保健品，包括ω-3脂肪酸、谷氨酰胺、精氨酸和多酚，具有抗炎和抗氧化特性，可促进愈合并降低感染风险。营养保健品中的益生菌和其他生物活性化合物有助于维持微生物群的平衡，减轻炎症，并刺激细胞再生。在研究设计、样本量、干预剂量和结果测量方面存在显著差异。这一证据强调了进一步进行精心设计的临床试验的必要性，以确定针对不同患者群体特定伤口类型的最佳剂量和组合。本系统综述已在PROSPERO（ID：1072091）中进行了前瞻性注册。
