Karageorgou Eftychia G, Kalogiouri Natasa P, Samanidou Victoria F
NBIS P.C. Cargo Inspections and ISO Certification, 54351 Thessaloniki, Greece.
Laboratory of Analytical Chemistry, School of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Molecules. 2025 Aug 31;30(17):3573. doi: 10.3390/molecules30173573.
This review provides a comprehensive overview of the recent green innovations in high-performance liquid chromatography (HPLC) for sustainable food analysis. It outlines the principles of green analytical chemistry and examines advances such as eco-friendly solvent systems, miniaturized and energy-efficient instrumentation, and greener sample preparation techniques. Key applications include the analysis of bioactive compounds, detection of contaminants and residues, and support for clean-label and sustainability claims. Furthermore, the review discusses relevant regulatory and certification frameworks, including ISO 14001, ISO 22000, and global food safety initiatives aligned with environmental, social, and governance standards. Persistent challenges, such as cost, limitations in analytical performance, and limited instrument availability, are highlighted, along with the need for reliable metrics to assess the environmental impact and effectiveness of green analytical practices. The review concludes by emphasizing the need for interdisciplinary collaboration among scientists, industry stakeholders, and regulatory bodies to support the wider adoption of sustainable HPLC practices in food laboratories.
本综述全面概述了高效液相色谱法（HPLC）在可持续食品分析方面的最新绿色创新。它概述了绿色分析化学的原理，并探讨了诸如环保溶剂系统、小型化和节能仪器以及更绿色的样品制备技术等进展。关键应用包括生物活性化合物的分析、污染物和残留物的检测，以及对清洁标签和可持续性声明的支持。此外，该综述还讨论了相关的监管和认证框架，包括ISO 14001、ISO 22000以及与环境、社会和治理标准相一致的全球食品安全倡议。文中强调了成本、分析性能限制和仪器可用性有限等持续存在的挑战，以及需要可靠的指标来评估绿色分析实践的环境影响和有效性。综述最后强调，科学家、行业利益相关者和监管机构之间需要跨学科合作，以支持食品实验室更广泛地采用可持续的HPLC实践。
