Malarz Janusz, Ryngwelska Iga, Stojakowska Anna
Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna Street 12, 31-343 Kraków, Poland.
Molecules. 2025 Sep 3;30(17):3596. doi: 10.3390/molecules30173596.
Despite the great structural diversity, plant lignans, coumarins, and xanthones share numerous biological activities, ranging from antimicrobial, anti-inflammatory, and antioxidant to antineoplastic and neuroprotective. The compounds, products of the shikimic acid biosynthetic pathway, also play an important role in plant-environment interactions. In a search for sustainable and renewable sources of these valuable plant products, numerous in vitro culture systems were investigated, including hairy root cultures. The -transformed root cultures of over 40 plant species representing 17 families of the plant kingdom were studied in this respect. The present review focuses on the hairy roots that may be efficient producers of valuable plant products with the prospect of use in the pharmaceutical, food, or cosmetics industry. In vitro culture systems based on hairy roots, which were used to elucidate the biosynthesis pathways of the high-added-value plant compounds, were also considered.
尽管植物木脂素、香豆素和呫吨酮在结构上具有很大的多样性，但它们具有多种生物活性，包括抗菌、抗炎、抗氧化、抗肿瘤和神经保护等。这些化合物是莽草酸生物合成途径的产物，在植物与环境的相互作用中也起着重要作用。为了寻找这些有价值的植物产品的可持续和可再生来源，人们研究了许多体外培养系统，包括毛状根培养。在这方面，对代表植物界17个科的40多种植物的转化根培养物进行了研究。本综述重点关注毛状根，它们可能是有价值的植物产品的高效生产者，有望用于制药、食品或化妆品行业。还考虑了基于毛状根的体外培养系统，该系统用于阐明高附加值植物化合物的生物合成途径。
