Chen Hongyan, Lyu Jiaxuan, Nie Jia, Wang Xuhui, Yang Na, Han Sheng, Zhou Mingliang
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China.
Department of Prosthodontics, Department of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai 200011, China.
Polymers (Basel). 2025 Aug 31;17(17):2384. doi: 10.3390/polym17172384.
A novel structure-functional-integrated particle featuring dual micromechanical interlocking property with resin matrix was constructed through surface modification of urchin-like serried hydroxyapatite (UHA) in this work, and the effect of this modification strategy on physicochemical and biological properties of dental resin composite was also investigated. A porous silica coating layer was anchored onto UHA surface via a simple template method in an oil-water biphase reaction system, and the coating time had a prominent effect on the coating thickness and morphology-structure of the particle. When these particles with different porous silica coating thickness were used as fillers for dental resin composite, results showed that UHA/PS5 (porous silica coating reaction time: 5 h) exhibited the optimal 3D urchin-like structure and a desirable porous silica coating thickness. Additionally, UHA/PS5 formed the best dual physical micromechanical interlocking structure when mixing with resin matrix, making the dental resin composites presented the desirable matrix/filler interfacial bonding, and the excellent physicochemical-biological properties, especially for flexural strength and water sorption-solubility. In vitro remineralization and cellular biological properties confirmed that the coating layer did not compromise their remineralization activity. The use of UHA/PSx provides a promising approach to develop strong, durable, and biocompatible DRCs.
在本研究中，通过对海胆状密集羟基磷灰石（UHA）进行表面改性，构建了一种与树脂基体具有双重微机械互锁性能的新型结构 - 功能一体化颗粒，并研究了这种改性策略对牙科树脂复合材料物理化学和生物学性能的影响。在油水双相反应体系中，通过简单的模板法在UHA表面锚定了一层多孔二氧化硅涂层，涂层时间对颗粒的涂层厚度和形态结构有显著影响。当这些具有不同多孔二氧化硅涂层厚度的颗粒用作牙科树脂复合材料的填料时，结果表明UHA/PS5（多孔二氧化硅涂层反应时间：5小时）呈现出最佳的三维海胆状结构和理想的多孔二氧化硅涂层厚度。此外，UHA/PS5与树脂基体混合时形成了最佳的双重物理微机械互锁结构，使牙科树脂复合材料具有理想的基体/填料界面结合以及优异的物理化学 - 生物学性能，尤其是弯曲强度和吸水性 - 溶解性。体外再矿化和细胞生物学性能证实涂层不会损害其再矿化活性。UHA/PSx的使用为开发坚固、耐用且生物相容的牙科树脂复合材料提供了一种有前景的方法。
