Wang Chunlei, Han Ning, Mao Caiyun, Chen Jiaxu, Cheng Nana, Zhao Jieyou, Song Yunjia, Sun Xutao
School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Int J Mol Sci. 2025 Aug 26;26(17):8257. doi: 10.3390/ijms26178257.
Ischemia-reperfusion (I/R) injury refers to the exacerbation of tissue or organ damage upon the restoration of blood flow after an ischemic event. Despite its widespread clinical occurrence, therapeutic interventions for I/R injury remain limited in efficacy, presenting a significant challenge in modern medicine. Garlic, traditionally consumed as a food, has gained considerable attention for its medicinal properties. Numerous animal studies have shown that garlic-derived organic polysulfides significantly improve nerve function scores post-I/R, reduce infarct size, mitigate inflammatory responses, and inhibit cellular apoptosis. Thus, understanding the role of garlic-derived organic polysulfides in I/R injury may unveil novel therapeutic targets. This review explores the protective effects and mechanisms of garlic-derived organic polysulfides on I/R injury in various organs, including the brain, spinal cord, myocardium, lungs, liver, kidneys, and testes, highlighting their potential in advancing treatment strategies for affected patients.
缺血再灌注（I/R）损伤是指缺血事件后血流恢复时组织或器官损伤的加重。尽管I/R损伤在临床上广泛发生，但针对其的治疗干预措施疗效仍然有限，这在现代医学中构成了重大挑战。大蒜作为一种传统食用的食物，因其药用特性而受到了广泛关注。大量动物研究表明，大蒜衍生的有机多硫化物可显著改善I/R后的神经功能评分，减小梗死面积，减轻炎症反应，并抑制细胞凋亡。因此，了解大蒜衍生的有机多硫化物在I/R损伤中的作用可能会揭示新的治疗靶点。本综述探讨了大蒜衍生的有机多硫化物对包括脑、脊髓、心肌、肺、肝、肾和睾丸在内的各种器官I/R损伤的保护作用及其机制，强调了它们在推进针对受影响患者的治疗策略方面的潜力。
