Barrino Federico, Giuliano Federica, Dispenza Clelia
Department of Engineering, University of Palermo, Viale delle Scienze 6, 90128 Palermo, Italy.
Int J Mol Sci. 2025 Aug 30;26(17):8450. doi: 10.3390/ijms26178450.
In recent years, research into the synthesis of innovative biomaterials for prosthetic applications has been increasingly growing. In particular, there is a demand for biomaterials with an excellent biocompatibility that can interact with biological fluids. This study involved the development of new silica (SiO)-based composite materials using the sol-gel technique and functionalization with ferulic acid (FA), a natural phenolic compound renowned for its biological properties. The synthesis involved controlling the hydrolysis and condensation of tetraethyl orthosilicate (TEOS) in acidic and alcoholic environments to incorporate ferulic acid into the sol phase matrix at different weight compositions (5, 10, 15, and 20 wt%). Fourier transform infrared spectroscopy analyses (FTIR) confirmed the successful incorporation of the bioactive compound, and in vitro tests revealed a good cytocompatibility and controlled ferulic acid release over time. These results demonstrate that the developed material shows promise as a bioactive coating for orthopedic prostheses, improving bone integration and reducing undesirable post-operative phenomena.
近年来，用于假体应用的新型生物材料合成研究日益增多。特别是，对具有优异生物相容性、能与生物流体相互作用的生物材料有需求。本研究涉及使用溶胶 - 凝胶技术开发新型二氧化硅（SiO）基复合材料，并使用阿魏酸（FA）进行功能化处理，阿魏酸是一种因其生物学特性而闻名的天然酚类化合物。合成过程包括在酸性和醇性环境中控制正硅酸乙酯（TEOS）的水解和缩合，以将阿魏酸以不同重量组成（5、10、15和20 wt%）掺入溶胶相基质中。傅里叶变换红外光谱分析（FTIR）证实了生物活性化合物的成功掺入，体外测试显示出良好的细胞相容性以及阿魏酸随时间的可控释放。这些结果表明，所开发的材料有望作为骨科假体的生物活性涂层，改善骨整合并减少不良术后现象。
