Barraza-Ortega Eunice, Gómez-Gil Bruno, García-Gasca Teresa, Lizárraga Dennise, Díaz Natalia, García-Gasca Alejandra
Laboratory of Molecular Biology and Tissue Culture, Centro de Investigación en Alimentación y Desarrollo, Avenida Sabalo Cerritos sn, Mazatlán 82112, Mexico.
Laboratory of Microbial Genomics, Centro de Investigación en Alimentación y Desarrollo, Avenida Sabalo Cerritos sn, Mazatlán 82112, Mexico.
Int J Mol Sci. 2025 Sep 3;26(17):8574. doi: 10.3390/ijms26178574.
Endocrine dysfunctions refer to alterations in hormone production, release, or regulation that can significantly impact health. In pregnant women or those planning pregnancy, these conditions may manifest as disorders such as polycystic ovary syndrome, hypothyroidism, endometriosis, gestational diabetes mellitus, and other metabolic issues, which could potentially cause infertility or pregnancy complications. Research and clinical experience indicate that hormones play a crucial role in basic physiology and are essential for overall health and well-being. At the same time, lifestyle-defined as daily habits related to nutrition, exercise, sleep, stress management, and other factors-directly influences microbial composition and hormonal regulation. The human microbiome, a diverse community of microorganisms residing within the human body, plays essential roles in supporting overall health. The increasing prevalence of hormonal disorders, especially in urban populations, has heightened interest in how modern lifestyles-characterised by sedentary habits, chronic stress, imbalanced diets, and inadequate sleep-may contribute to the development or aggravation of these conditions, leading to higher infertility rates or pregnancy complications if untreated. This review investigates the interaction between hormonal dysfunction, the human microbiome, and lifestyle factors, with a focus on their effects on pregnant women and those seeking to conceive. Its purpose is to provide a comprehensive overview of the underlying pathophysiological mechanisms and to examine preventative and therapeutic approaches that could alter these patterns.
内分泌功能障碍是指激素产生、释放或调节的改变，这些改变会对健康产生重大影响。对于孕妇或计划怀孕的女性来说，这些情况可能表现为多囊卵巢综合征、甲状腺功能减退、子宫内膜异位症、妊娠期糖尿病等疾病以及其他代谢问题，这些问题可能会导致不孕或妊娠并发症。研究和临床经验表明，激素在基础生理学中起着关键作用，对整体健康和幸福至关重要。同时，生活方式（定义为与营养、运动、睡眠、压力管理等相关的日常习惯）直接影响微生物组成和激素调节。人体微生物群是存在于人体内的多种微生物群落，在维持整体健康方面发挥着重要作用。激素紊乱的患病率不断上升，尤其是在城市人群中，这引发了人们对现代生活方式（其特点是久坐不动、慢性压力、饮食不均衡和睡眠不足）如何可能导致这些疾病的发生或加重的兴趣，如果不加以治疗，可能会导致更高的不孕率或妊娠并发症。这篇综述研究了激素功能障碍、人体微生物群和生活方式因素之间的相互作用，重点关注它们对孕妇和寻求怀孕的女性的影响。其目的是全面概述潜在的病理生理机制，并研究可以改变这些模式的预防和治疗方法。
