Chen Li, Yan Hong, Di Shanshan, Guo Chao, Zhang Huan, Zhang Shiqi, Gold Andrew, Wang Yu, Hu Ming, Wu Dayong, Johnson Caroline H, Wang Xinquan, Zhu Jiangjiang
Human Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH, 43210, USA.
James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Nat Commun. 2025 May 10;16(1):4355. doi: 10.1038/s41467-025-59747-6.
Pesticides can modulate gut microbiota composition, but their specific effects on it remain largely elusive. In our study, we show that pesticides inhibit or promote the growth of various gut microbial species and can be accumulated to prolong their presence in the host. Pesticide exposure also induces significant alterations in gut bacterial metabolism, as reflected by changes in hundreds of metabolites. We generate a pesticide-gut microbiota-metabolite network that not only reveals pesticide-sensitive gut bacteria species but also reports specific metabolic changes in 306 pesticide-gut microbiota pairs. Using an in vivo mouse model, we further demonstrate the interactions of a representative pesticide-gut microbiota pair and verify the inflammation-inducing effects of pesticide exposure on the host, mediated by microbially dysregulated lipid metabolism. Taken together, our findings generate a comprehensive atlas of pesticide-gut microbiota-metabolite interactions atlas and shed light on the molecular mechanisms by which pesticides affect host health via gut microbiota-modulated metabolism.
农药可调节肠道微生物群的组成，但其具体影响在很大程度上仍不清楚。在我们的研究中，我们表明农药会抑制或促进各种肠道微生物物种的生长，并且可以在宿主体内积累以延长其存在时间。农药暴露还会诱导肠道细菌代谢的显著变化，这通过数百种代谢物的变化得以体现。我们构建了一个农药-肠道微生物群-代谢物网络，该网络不仅揭示了对农药敏感的肠道细菌物种，还报告了306对农药-肠道微生物群中的特定代谢变化。使用体内小鼠模型，我们进一步证明了一对具有代表性的农药-肠道微生物群之间的相互作用，并验证了农药暴露通过微生物失调的脂质代谢对宿主产生的炎症诱导作用。综上所述，我们的研究结果生成了一份农药-肠道微生物群-代谢物相互作用的综合图谱，揭示了农药通过肠道微生物群调节的代谢影响宿主健康的分子机制。
