Yang Shuzhe, Bai Zhongyuan, Zhang Fei, Cui Wei, Bu Peng, Bai Wenqi, Xi Yanfeng
Second Clinical Medical School, Shanxi Medical University, Taiyuan, China.
First Clinical Medical School, Shanxi Medical University, Taiyuan, China.
BMC Gastroenterol. 2025 Feb 17;25(1):84. doi: 10.1186/s12876-025-03643-2.
Tumor blood vessels are tortuous and dilated, contributing to the aberrant tumor microenvironment. CD93 is a newly reported transmembrane receptor, mainly expressed in tumor endothelial cells, that has demonstrated prognostic value in some cancer types. However, the role of CD93 in the vasculature of colorectal cancer (CRC) tissues and its prognostic significance remain unknown. It is therefore necessary to explore the effect of CD93 in patients with CRC.
We detected the expression of CD93 in human CRC tissues using immunohistochemistry. We then examined the correlation between CD93 expression and clinicopathological factors in cancer tissues from 134 patients with CRC.
CD93 expression levels were higher in CRC vessels than in vessels in adjacent normal tissues. Upregulation of CD93 was associated with tumor site and microsatellite instability. CD93 protein expression was positively related to macrophage infiltration in CRC. High expression of CD93 may indicate normalization of the tumor vasculature and was associated with better overall survival.
CD93 was highly expressed in CRC vessels and correlated with infiltration of immune cells. Our findings reveal that vascular normalization and patient prognosis can be predicted by detecting CD93 expression in CRC tumor tissues.
肿瘤血管迂曲扩张，导致肿瘤微环境异常。CD93是一种新报道的跨膜受体，主要表达于肿瘤内皮细胞，在某些癌症类型中已显示出预后价值。然而，CD93在结直肠癌（CRC）组织血管中的作用及其预后意义尚不清楚。因此，有必要探讨CD93在CRC患者中的作用。
我们采用免疫组织化学方法检测了人CRC组织中CD93的表达。然后，我们研究了134例CRC患者癌组织中CD93表达与临床病理因素之间的相关性。
CRC血管中CD93表达水平高于相邻正常组织中的血管。CD93的上调与肿瘤部位和微卫星不稳定性有关。CD93蛋白表达与CRC中的巨噬细胞浸润呈正相关。CD93的高表达可能表明肿瘤血管正常化，并与更好的总生存期相关。
CD93在CRC血管中高表达，并与免疫细胞浸润相关。我们的研究结果表明，通过检测CRC肿瘤组织中CD93的表达可以预测血管正常化和患者预后。
