Guglielmero Luca, Mero Angelica, Koutsoumpos Spyridon, Kripotou Sotiria, Moutzouris Konstantinos, Guazzelli Lorenzo, Mezzetta Andrea
Dipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy.
Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy.
Int J Mol Sci. 2025 Sep 4;26(17):8625. doi: 10.3390/ijms26178625.
The search for more sustainable alternatives to traditional organic solvents, in the frame of the green chemistry approach, is leading to an increasing interest toward the exploration of deep eutectic solvents (DESs), especially natural-based ones (NADESs). The great ferment in the use of DESs as innovative media for many applications and in the research of novel types of DESs is not matched by an equal rigor in their characterization and in the study of their physico-chemical characteristics. Nevertheless, it is evident how comparative studies encompassing the investigation of a wide range of properties in relationship with the DESs structures would be beneficial for a rational development of the field. In this work a panel of DESs featuring choline acetate, L-carnitine and L-proline as hydrogen bond acceptor constituents (HBAs) and ethylene glycol, glycerol and levulinic acid as hydrogen bond donor constituents (HBDs) in 1:2 and 1:3 molar ratios have been prepared and characterized. Their density, viscosity and optical properties have been thoroughly investigated at various temperatures, analyzing the influence of their composition in terms of type of HBA, type of HBD and molar ratio on their properties. All the proposed DESs have also been thermally characterized by TGA and DSC, providing a description of their thermal behavior in a wide range of temperature and determining their thermal stability and thermal degradation profile.
在绿色化学方法的框架内，寻找比传统有机溶剂更具可持续性的替代品，使得人们对探索深共熔溶剂（DESs），尤其是天然基深共熔溶剂（NADESs）的兴趣日益浓厚。DESs作为许多应用的创新介质以及新型DESs的研究备受关注，但其表征以及物理化学特性研究却缺乏同等的严谨性。然而，显然涵盖对与DESs结构相关的广泛性质进行研究的比较研究，将有助于该领域的合理发展。在这项工作中，制备并表征了一组DESs，它们以醋酸胆碱、L-肉碱和L-脯氨酸作为氢键受体成分（HBAs），以乙二醇、甘油和乙酰丙酸作为氢键供体成分（HBDs），摩尔比分别为1:2和1:3。在不同温度下对它们的密度、粘度和光学性质进行了深入研究，分析了HBA类型、HBD类型和摩尔比等组成因素对其性质的影响。所有提出的DESs还通过热重分析（TGA）和差示扫描量热法（DSC）进行了热表征，描述了它们在广泛温度范围内的热行为，并确定了它们的热稳定性和热降解曲线。
