重新探讨深共熔溶剂的物理化学性质及其应用。

Revisiting the Physicochemical Properties and Applications of Deep Eutectic Solvents.

机构信息

Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, India.

Department of Chemistry, Dr. B. R. Ambedkar National Institute of Technology, Jalandhar 144011, India.

出版信息

Molecules. 2022 Feb 17;27(4):1368. doi: 10.3390/molecules27041368.

Recently, deep eutectic solvent (DES) or ionic liquid (IL) analogues have been considered as the newest green solvent, demonstrating the potential to replace harsh volatile organic solvents. DESs are mainly a combination of two compounds: hydrogen bond acceptor (HBA) and hydrogen bond donor (HBD), which have the ability to interact through extensive hydrogen bonds. A thorough understanding of their physicochemical properties is essential, given their successful applications on an industrial scale. The appropriate blend of HBA to HBD can easily fine-tune DES properties for desired applications. In this context, we have reviewed the basic information related to DESs, the two most studied physicochemical properties (density and viscosity), and their performance as a solvent in (i) drug delivery and (ii) extraction of biomolecules. A broader approach of various factors affecting their performance has been considered, giving a detailed picture of the current status of DESs in research and development.

最近，深共晶溶剂（DES）或离子液体（IL）类似物已被视为最新的绿色溶剂，有望替代苛刻的挥发性有机溶剂。DES 主要由两种化合物组成：氢键受体（HBA）和氢键供体（HBD），它们具有通过广泛氢键相互作用的能力。鉴于它们在工业规模上的成功应用，深入了解其物理化学性质至关重要。HBA 与 HBD 的适当混合可以轻松调整 DES 特性以满足预期应用的需求。在这种情况下，我们回顾了 DES 相关的基本信息、最受研究的两种物理化学性质（密度和粘度），以及它们作为溶剂在（i）药物传递和（ii）生物分子提取中的性能。考虑了影响其性能的各种因素的更广泛方法，详细描述了 DES 在研究和开发中的现状。