Wang Wentao, Han Fengze, He Xinmiao, Zhao Shihan, Zou Ziluo, Tian Ming, Chen Heshu, Wu Saihui, Sun Yan, Jiang Yaokun, Sun Meiqin, Zhang Libing, Yu Kunzhi, Wang Yao, Tian Yaguang, Jiang Xinpeng, Liu Di
Key Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture, Animal Husbandry Research Institute, Heilongjiang Academy of Agricultural Sciences, No. 368 Xuefu Road, Harbin 150086, China.
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Int J Mol Sci. 2025 Sep 8;26(17):8746. doi: 10.3390/ijms26178746.
In recent years, outbreaks of Seneca Valley virus (SVV) in pig farms have raised concerns about disease resistance in different pig breeds. Min pigs are an excellent local pig breed in China, but the breed's strong disease resistance mechanism has not been clearly investigated. In this study, Min pigs and Landrace pigs were challenged with SVV, and the differences in pathogenicity between SVV-infected Min and Landrace pigs were evaluated in terms of production performance, survival rate, immune cell activity, pathological changes, viral titer, and cytokine expression. The results show that the mortality rate in Min pigs was significantly lower than that in Landrace pigs without substantial weight loss. The copy number of SVV RNA in the intestinal mucosa of Min pigs was lower than that in Landrace pigs. Additionally, the IgA and IgG titers in Min pigs were higher than those in Landrace pigs. Both the absolute number and percentage of M1 macrophages were elevated in Min pigs relative to Landrace pigs. This study is the first to identify differences in macrophage activity between SVV-infected Min pigs and Landrace pigs. The presented results indicate the potential research value of studying innate immunity differences in disease resistance between pig breeds.
近年来，养猪场中塞内卡山谷病毒（SVV）的爆发引发了人们对不同猪品种抗病性的关注。民猪是中国优良的地方猪种，但其强大的抗病机制尚未得到明确研究。在本研究中，用SVV对民猪和长白猪进行攻毒，并从生产性能、存活率、免疫细胞活性、病理变化、病毒滴度和细胞因子表达等方面评估了感染SVV的民猪和长白猪之间的致病性差异。结果表明，民猪的死亡率显著低于长白猪，且体重无明显减轻。民猪肠道黏膜中SVV RNA的拷贝数低于长白猪。此外，民猪的IgA和IgG滴度高于长白猪。相对于长白猪，民猪中M1巨噬细胞的绝对数量和百分比均有所升高。本研究首次确定了感染SVV的民猪和长白猪之间巨噬细胞活性的差异。所呈现的结果表明了研究猪品种抗病性中固有免疫差异的潜在研究价值。
