Schäfer Alexander, Franzoni Giulia, Netherton Christopher L, Hartmann Luise, Blome Sandra, Blohm Ulrike
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany.
Department of Animal Health, Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Pathogens. 2022 Feb 20;11(2):274. doi: 10.3390/pathogens11020274.
African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T cell responses are impacted by the infection as well. The complex responses remain not well understood, and, consequently, there is no commercially available vaccine. Here, we review the current knowledge about the induction of antiviral T cell responses by cells of the myeloid lineage, as well as T cell responses in infected animals, recent efforts in vaccine research, and T cell epitopes present in ASFV.
非洲猪瘟病毒(ASFV)仍然是全球猪群面临的一大威胁。ASFV感染会引发一种出血性疾病,在欧亚大陆的家猪和野猪中致死率高达100%。虽然髓样细胞是ASFV的主要靶细胞,但感染也会影响T细胞反应。这些复杂的反应仍未得到充分了解,因此目前尚无商业化可用疫苗。在此,我们综述了有关髓系细胞系诱导抗病毒T细胞反应的现有知识,以及感染动物中的T细胞反应、疫苗研究的最新进展,以及ASFV中存在的T细胞表位。