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右心房血栓并发左心室辅助装置植入适应证:一例临床病例研究

Right Atrial Thrombus Complicating LVAD Candidacy: A Clinical Case Study.

作者信息

Alak Cetin, Desai Aarti, El-Sabbagh Abdallah, Yip Daniel, Goswami Rohan

机构信息

Division of Heart Failure and Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA.

Department of Cardiovascular Diseases, Mayo Clinic, Jacksonville, FL 32224, USA.

出版信息

J Clin Med. 2025 Sep 4;14(17):6242. doi: 10.3390/jcm14176242.

Abstract

: Right atrial thrombus (RAT), though rare, carries a high risk of pulmonary or systemic embolism and a 25-44% mortality rate. In LVAD candidates, coexisting RAT significantly complicates perioperative management due to their critical condition and high risk of decompensation during surgery. Percutaneous thrombectomy offers a less invasive, lower-risk alternative to open surgery, enabling faster recovery. : We present a case of a 76-year-old male with ischemic cardiomyopathy and heart failure secondary to Adriamycin chemotherapy with an ejection fraction (EF) of 26%, diabetes mellitus, and stage 3 chronic kidney disease, scheduled for left ventricular assist device (LVAD) implantation. Preoperative echocardiography revealed a large, multilobulated, mobile thrombus in the right atrium. Given the high surgical risk and thrombus mobility, percutaneous thrombectomy using the AngioVac system (Angiodynamics, Latham, NY, USA) was performed. The thrombus was successfully removed, and the patient was discharged on apixaban for long-term anticoagulation. Advanced medical therapy and transplant/durable LVAD evaluation were delayed by 35 days to allow for the stabilization of any postoperative effects. : This case underscores the efficacy of percutaneous thrombectomy as a bridge to LVAD in high-risk patients, reducing thromboembolic complications and supporting safe LVAD implantation.

摘要

右心房血栓(RAT)虽罕见,但有很高的肺栓塞或全身栓塞风险,死亡率为25% - 44%。在左心室辅助装置(LVAD)植入候选患者中,并存的RAT因其病情危急且手术期间失代偿风险高,显著使围手术期管理复杂化。经皮血栓切除术为开放手术提供了一种侵入性较小、风险较低的替代方法,能使患者恢复更快。

我们报告一例76岁男性患者,患有缺血性心肌病和因阿霉素化疗继发的心力衰竭,射血分数(EF)为26%,患有糖尿病和3期慢性肾病,计划植入左心室辅助装置(LVAD)。术前超声心动图显示右心房有一个大的、多叶的、可移动血栓。鉴于手术风险高和血栓的可移动性,使用AngioVac系统(美国纽约州拉瑟姆市Angiodynamics公司)进行了经皮血栓切除术。血栓被成功清除,患者出院时服用阿哌沙班进行长期抗凝。先进的药物治疗以及移植/耐用LVAD评估推迟了35天,以便术后任何影响得以稳定。

该病例强调了经皮血栓切除术作为高危患者LVAD植入桥梁的有效性,可减少血栓栓塞并发症并支持安全的LVAD植入。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbb/12429423/32e9a3b9285f/jcm-14-06242-g001.jpg

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