Hoover D, Bendele S A, Wightman S R, Thompson C Z, Hoyt J A
Lab Anim Sci. 1985 Dec;35(6):635-41.
A spontaneous outbreak of enteric disease with high morbidity and mortality occurred in preweanling rats on a multigeneration toxicity study. The rats had a large number of gram-positive cocci on the surface of villi in the small intestine without associated inflammatory change. Ultrastructural study identified filamentous attachments between adjacent bacteria, and between bacteria and morphologically normal microvilli. The organism was isolated and identified as Streptococcus sp. The disease was reproduced in rat pups by inoculating dams and newborn rats with pure cultures of the Streptococcus. Streptococcal enteropathy is a previously unreported disease in rats.
在一项多代毒性研究中，断奶前大鼠发生了一次高发病率和死亡率的肠道疾病自发暴发。这些大鼠小肠绒毛表面有大量革兰氏阳性球菌，且无相关炎症变化。超微结构研究发现相邻细菌之间以及细菌与形态正常的微绒毛之间存在丝状附着物。该病原体被分离出来并鉴定为链球菌属。通过给母鼠和新生大鼠接种链球菌纯培养物，在幼鼠中再现了这种疾病。链球菌性肠病是大鼠中一种以前未报道过的疾病。
