Obaid Raghad, Alkazemi Dalal
Kuwait Cancer Control Center, P.O. Box 42263, Shuwaikh 70654, Kuwait.
Department of Food Science and Nutrition, College of Life Sciences, Kuwait University, Shadadiya, P.O. Box 5969, Safat 13060, Kuwait.
Nutrients. 2025 Aug 27;17(17):2770. doi: 10.3390/nu17172770.
Malnutrition is a common but underrecognized complication in colorectal cancer (CRC), contributing to poor treatment outcomes and reduced quality of life. Regional data from the Gulf remains limited. This study assessed the prevalence of malnutrition and nutrition impact symptoms (NISs) among CRC patients in Kuwait. It evaluated the diagnostic performance of the PG-SGA Short Form (PG-SGA SF) in comparison to the full PG-SGA and the Malnutrition Screening Tool (MST). A cross-sectional study was conducted among 65 CRC outpatients at the Kuwait Cancer Control Center. Nutritional status was assessed using the full PG-SGA, PG-SGA SF, and MST. Dietary intake, anthropometry, biochemical parameters, and NISs were collected. Logistic regression identified independent predictors of malnutrition, and the performance of the tool was evaluated using kappa statistics and diagnostic accuracy metrics. Malnutrition (PG-SGA B/C) was identified in 61.4% of patients. Loss of appetite, dry mouth, and nausea were significantly associated with malnutrition ( < 0.00385); dry mouth independently predicted malnutrition (OR: 17.65, 95% CI: 2.02-154.19, = 0.009). BMI was not predictive, but reduced mid-arm circumference was significantly associated. PG-SGA SF showed strong agreement with the full PG-SGA (κ = 0.75), with high sensitivity (87.2%) and specificity (88.5%), outperforming MST (κ = 0.38). Only 23.5% of moderately malnourished patients were referred to a dietitian. Malnutrition and NIS are highly prevalent among Kuwaiti CRC patients. PG-SGA SF is a valid and efficient screening tool that should replace MST in oncology settings. Symptom-informed screening and structured referral protocols are crucial for enhancing nutrition care.
营养不良是结直肠癌（CRC）中一种常见但未得到充分认识的并发症，会导致治疗效果不佳和生活质量下降。海湾地区的相关数据仍然有限。本研究评估了科威特CRC患者中营养不良和营养影响症状（NIS）的患病率。它评估了PG-SGA简表（PG-SGA SF）与完整PG-SGA和营养不良筛查工具（MST）相比的诊断性能。在科威特癌症控制中心对65名CRC门诊患者进行了一项横断面研究。使用完整的PG-SGA、PG-SGA SF和MST评估营养状况。收集饮食摄入量、人体测量学、生化参数和NIS。逻辑回归确定了营养不良的独立预测因素，并使用kappa统计量和诊断准确性指标评估工具的性能。61.4%的患者被确定为营养不良（PG-SGA B/C）。食欲不振、口干和恶心与营养不良显著相关（<0.00385）；口干独立预测营养不良（OR：17.65，95%CI：2.02-154.19，=0.009）。BMI无预测性，但上臂中部周长减小与之显著相关。PG-SGA SF与完整的PG-SGA显示出高度一致性（κ=0.75），具有高敏感性（87.2%）和特异性（88.5%），优于MST（κ=0.38）。只有23.5%的中度营养不良患者被转诊至营养师处。营养不良和NIS在科威特CRC患者中非常普遍。PG-SGA SF是一种有效且高效的筛查工具，应在肿瘤学环境中取代MST。基于症状的筛查和结构化转诊方案对于加强营养护理至关重要。
