Ameliorates Oxidative Stress and Inflammation to Inhibit Atherosclerosis Development in ApoE Mice.

Atherosclerosis is a chronic vascular disease triggered by lipid accumulation. is rich in various bioactive compounds that have anti-inflammatory, antioxidant, and hypolipidemic properties. The specific beneficial effects of on atherosclerosis and its underlying mechanisms require further investigation. : In this study, ApoE mice were utilized as models of atherosclerosis induced by a high-fat diet (HFD) to investigate the effects of Analyses of gut microbiota and serum metabolomics were conducted to elucidate the potential mechanism. In HFD-fed ApoE mice, significantly inhibited the increase in body weight, regulated lipid levels, and alleviated aortic lesions. also modulated the abundance of intestinal flora such as and and altered the levels of serum metabolites, including 12(S)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(S)-HETE) and N-acetyl galactosamine 4-sulfate. Furthermore, alleviated oxidative stress and inflammatory responses, thereby mitigating atherosclerosis via the Nrf2/NF-κB signaling pathway. These findings suggest that may serve as a potential therapeutic strategy for atherosclerosis.