Zhao Jundi, Ma Siyu, Hu Yifan, Ling Jing, Wang Zhuqian, Wang Jingyu, Chen Junliang, Zhang Yongfeng
Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China.
College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Nutrients. 2025 Aug 28;17(17):2799. doi: 10.3390/nu17172799.
Atherosclerosis is a chronic vascular disease triggered by lipid accumulation. is rich in various bioactive compounds that have anti-inflammatory, antioxidant, and hypolipidemic properties. The specific beneficial effects of on atherosclerosis and its underlying mechanisms require further investigation. : In this study, ApoE mice were utilized as models of atherosclerosis induced by a high-fat diet (HFD) to investigate the effects of Analyses of gut microbiota and serum metabolomics were conducted to elucidate the potential mechanism. In HFD-fed ApoE mice, significantly inhibited the increase in body weight, regulated lipid levels, and alleviated aortic lesions. also modulated the abundance of intestinal flora such as and and altered the levels of serum metabolites, including 12(S)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(S)-HETE) and N-acetyl galactosamine 4-sulfate. Furthermore, alleviated oxidative stress and inflammatory responses, thereby mitigating atherosclerosis via the Nrf2/NF-κB signaling pathway. These findings suggest that may serve as a potential therapeutic strategy for atherosclerosis.
动脉粥样硬化是一种由脂质堆积引发的慢性血管疾病。富含多种具有抗炎、抗氧化和降血脂特性的生物活性化合物。其对动脉粥样硬化的具体有益作用及其潜在机制尚需进一步研究。：在本研究中，将载脂蛋白E（ApoE）小鼠用作高脂饮食（HFD）诱导的动脉粥样硬化模型，以研究其作用效果。进行了肠道微生物群和血清代谢组学分析以阐明潜在机制。在喂食HFD的ApoE小鼠中，显著抑制了体重增加，调节了脂质水平，并减轻了主动脉病变。还调节了诸如和等肠道菌群的丰度，并改变了血清代谢物水平，包括12（S）-羟基-5Z，8Z，10E，14Z-二十碳四烯酸（12（S）-HETE）和N-乙酰半乳糖胺4-硫酸盐。此外，通过Nrf2/NF-κB信号通路减轻氧化应激和炎症反应，从而减轻动脉粥样硬化。这些发现表明，可能成为动脉粥样硬化的一种潜在治疗策略。
