Fleigle Dayelise, Brumitt Jason, McCarthy Erika, Adelman Travis, Asbell Corey
Doctor of Medical Science Program, College of Medical Science, George Fox University, Newberg, OR 97132, USA.
Doctor of Physical Therapy Program, College of Allied Health, George Fox University, Newberg, OR 97132, USA.
Nutrients. 2025 Sep 7;17(17):2893. doi: 10.3390/nu17172893.
: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy experienced by females. Diagnosis of PCOS is established when at least two of the following are present: hyperandrogenism, oligo-anovulation, and/or polycystic ovaries. Conservative treatment for PCOS includes dietary modifications and physical activity. The purpose of this scoping review was to evaluate the efficacy of a ketogenic diet in improving biochemical measures and reducing the severity of PCOS symptoms. : CINAHL, PubMed, and Google Scholar databases were searched to find research published in peer-reviewed journals between 2019 and 2025. An article was included in this scoping review if the study assessed the effectiveness of a ketogenic diet on improving the signs and symptoms in patients with PCOS. Eight studies met the inclusion criteria. Weight loss was achieved by subjects who adopted a very low-calorie ketogenic diet (VLCKD), low-calorie ketogenic diet (LCKD), classic ketogenic diet (CKD), or a Mediterranean eucaloric ketogenic diet (KEMEPHY). Patients with PCOS who consumed a ketogenic diet experienced improved biochemical measures, including androgen levels, lipid levels, HOMA-IR, blood glucose, insulin, LH/FSH ratio, DHEAS, SHBG, AFC, and AMH. A ketogenic diet was also associated with improvements in menstruation, fertility, and OHSS. : Adopting a short-term ketogenic diet may have positive health benefits for patients with PCOS.
多囊卵巢综合征（PCOS）是女性最常见的内分泌疾病。当出现以下至少两种情况时，可确诊为PCOS：高雄激素血症、少排卵和/或多囊卵巢。PCOS的保守治疗包括饮食调整和体育锻炼。本综述的目的是评估生酮饮食在改善生化指标和减轻PCOS症状严重程度方面的疗效。检索了CINAHL、PubMed和谷歌学术数据库，以查找2019年至2025年在同行评审期刊上发表的研究。如果研究评估了生酮饮食对改善PCOS患者体征和症状的有效性，则该文章纳入本综述范围。八项研究符合纳入标准。采用极低热量生酮饮食（VLCKD）、低热量生酮饮食（LCKD）、经典生酮饮食（CKD）或地中海热量平衡生酮饮食（KEMEPHY）的受试者实现了体重减轻。食用生酮饮食的PCOS患者生化指标得到改善，包括雄激素水平、血脂水平、胰岛素抵抗指数（HOMA-IR）、血糖、胰岛素、促黄体生成素/促卵泡生成素比值（LH/FSH）、硫酸脱氢表雄酮（DHEAS）、性激素结合球蛋白（SHBG）、窦卵泡计数（AFC）和抗苗勒管激素（AMH）。生酮饮食还与月经、生育能力和卵巢过度刺激综合征（OHSS）的改善有关。采用短期生酮饮食可能对PCOS患者有积极的健康益处。
