Patiño-Cardona Silvana, Garrido-Miguel Miriam, Pascual-Morena Carlos, Berlanga-Macías Carlos, Lucerón-Lucas-Torres Maribel, Alfaro-González Sofía, Martínez-García Irene
Health and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain.
Faculty of Nursing, Universidad de Castilla-La Mancha, 02006 Albacete, Spain.
J Cardiovasc Dev Dis. 2024 Nov 25;11(12):377. doi: 10.3390/jcdd11120377.
Coenzyme Q10 (CoQ10) has been suggested as an adjunct therapy for endocrine and metabolic disorders. The aim of this study was to synthesise the evidence for the effect of CoQ10 supplementation on lipid and/or glycaemic alterations, including total cholesterol (TC), LDL- and HDL-cholesterol (LDL-C and HDL-C), lipoprotein a, fasting blood glucose (FBG), haemoglobin A1c (HbA1c), fasting insulin and Homeostatic Model Assessment of Insulin Resistance. A systematic search was conducted in Medline, Scopus, Web of Science and the Cochrane Library from their inception to July 2024. Meta-analyses that evaluated the effect of CoQ10 on the lipid or glycaemic profiles were included. Results were expressed as mean difference (MD) or standardised mean difference (SMD). CoQ10 showed an effect on the glycaemic profile, especially on FBG (MD from -11.21 to -5.2 mg/dL, SMD from -2.04 to -0.17) and on HbA1c (MD from -1.83 to -0.12%, SMD of -0.30). CoQ10 may also have an effect on the lipid profile, such as TC, triglycerides, HDL-C and even LDL-C, although the inconsistency of the results was somewhat higher. Supplementation with CoQ10 may be beneficial, especially in populations with diabetes mellitus or other endocrine and metabolic disorders. It could also have some effect on lipid parameters, which, together with the above, may reduce cardiovascular morbidity and mortality, although this is something that needs further research.
辅酶Q10（CoQ10）已被提议作为内分泌和代谢紊乱的辅助治疗方法。本研究的目的是综合补充CoQ10对脂质和/或血糖改变影响的证据，包括总胆固醇（TC）、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇（LDL-C和HDL-C）、脂蛋白a、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、空腹胰岛素以及胰岛素抵抗的稳态模型评估。从创刊至2024年7月，在Medline、Scopus、科学网和考克兰图书馆进行了系统检索。纳入评估CoQ10对脂质或血糖谱影响的荟萃分析。结果以平均差（MD）或标准化平均差（SMD）表示。CoQ10对血糖谱有影响，尤其是对FBG（MD为-11.21至-5.2mg/dL，SMD为-2.04至-0.17）和HbA1c（MD为-1.83至-0.12%，SMD为-0.30）。CoQ10也可能对脂质谱有影响，如TC、甘油三酯、HDL-C甚至LDL-C，尽管结果的不一致性略高。补充CoQ10可能有益，尤其是在糖尿病或其他内分泌和代谢紊乱人群中。它也可能对脂质参数有一些影响，这与上述情况一起，可能会降低心血管发病率和死亡率，尽管这需要进一步研究。
