Jaton A L, Vigouret J M
J Pharmacol. 1985;16 Suppl 3:51-6.
Rats were trained in 4 consecutive trials to obtain a liquid reward in a labyrinth system. Drugs were given s.c. 2-4 hours before each trial, and starting time (ST), running time (RT) and number of errors (NE) were recorded on the fourth trial. Hydergine reduced NE independently of its effect on ST and RT. Dihydroergocristine and dihydroergocornine prolonged ST, dihydro-alpha-ergokryptine reduced NE whilst dihydro-beta-ergokryptine did not induce any significant effect on the three parameters. These results demonstrated that none of the Hydergine components exerts a similar effect to that of Hydergine in this model. It is also known that Hydergine influences neurotransmitters like serotonin, dopamine, noradrenaline and acetylcholine in vivo and in vitro. Therefore, the effects of Hydergine on cognitive functions in rats appear to be the consequence of its different actions on the cerebral transmission.
大鼠在迷宫系统中连续进行4次试验以获取液体奖励。每次试验前2 - 4小时皮下注射药物，并在第四次试验时记录开始时间（ST）、奔跑时间（RT）和错误次数（NE）。喜得镇降低了错误次数，且与它对开始时间和奔跑时间的影响无关。双氢麦角汀和双氢麦角柯宁延长了开始时间，双氢α - 麦角隐亭减少了错误次数，而双氢β - 麦角隐亭对这三个参数均未产生任何显著影响。这些结果表明，在该模型中，喜得镇的任何一种成分都不会产生与喜得镇类似的效果。还已知喜得镇在体内和体外都会影响血清素、多巴胺、去甲肾上腺素和乙酰胆碱等神经递质。因此，喜得镇对大鼠认知功能的影响似乎是其对大脑传递的不同作用的结果。
