Le Poncin-Lafitte M, Rapin J R, Duterte D, Galiez V, Lamproglou I
J Pharmacol. 1985;16 Suppl 3:57-63.
In the present work, a study of the number of functional receptors has been made with 3HQNB given to resting awaken animals during a learning process. Ageing leads to a decrease in the ability of learning associated with an increase in the number of large movements. The number of cholinergic receptors is also reducel if we compare 22 month old animals with 4 month old animals maintained under usual conditions. Learning conditioning leads to a stimulation of the cholinergic system with a release of acetylcholine. The mediator takes the 3HQNB out of its fixation areas which causes an apparent decrease in the number of receptors. This result is more significant in young animals than in aged ones because of the possibility of activation in the cholinergic system. The treatment by dihydroergotoxine partially re-establishes the learning abilities in animals and, at the same time, increases the number of cholinergic receptors This effect could explain the actions of this drug on the memory process in ageing persons.
在本研究中，在学习过程中给处于静息觉醒状态的动物注射3 -羟基喹啉 - N -丁基溴化物（3HQNB），对功能性受体的数量进行了研究。衰老导致学习能力下降，同时大幅度动作的数量增加。如果将在正常条件下饲养的22月龄动物与4月龄动物进行比较，胆碱能受体的数量也会减少。学习条件反射会刺激胆碱能系统，导致乙酰胆碱释放。介质将3HQNB从其固定区域带出，这导致受体数量明显减少。由于胆碱能系统激活的可能性，这一结果在幼龄动物中比在老龄动物中更为显著。双氢麦角毒碱治疗可部分恢复动物的学习能力，同时增加胆碱能受体的数量。这种效应可以解释该药物对老年人记忆过程的作用。
