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长期给予二氢麦角毒碱可增加老年大鼠脑内毒蕈碱胆碱能受体结合。

Chronic dihydroergotoxine administration increases muscarinic cholinergic receptor binding in aged-rat brain.

作者信息

Ogawa N, Mizukawa K, Sora I

机构信息

Institute for Neurobiology, Okayama University Medical School, Japan.

出版信息

Res Commun Chem Pathol Pharmacol. 1987 Aug;57(2):149-59.

PMID:3659567
Abstract

Changes in the distribution and densities of muscarinic cholinergic receptors (mCh-R) and the effects of dihydroergotoxine (DHET) administration on these changes were studied in the aged-rat brain by in vitro autoradiography. mCh-R binding in the brain was markedly reduced in aged rats as compared with young adult rats, but chronic administration of DHET specifically recovered mCh-R binding in the temporal cortex and hippocampus.

摘要

通过体外放射自显影技术，研究了老年大鼠脑中毒蕈碱型胆碱能受体（mCh-R）分布和密度的变化，以及给予二氢麦角毒碱（DHET）对这些变化的影响。与年轻成年大鼠相比，老年大鼠脑中的mCh-R结合显著减少，但长期给予DHET可特异性恢复颞叶皮质和海马中的mCh-R结合。

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Res Commun Chem Pathol Pharmacol. 1987 Aug;57(2):149-59.
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引用本文的文献

1
A method for parallel determination of choline acetyltransferase and muscarinic cholinergic receptors: application in aged-rat brain.
Neurochem Res. 1988 Oct;13(10):951-5. doi: 10.1007/BF00970767.
2
Effects of chronic bifemelane hydrochloride administration on receptors for N-methyl-D-aspartate in the aged-rat brain.
Neurochem Res. 1992 Jul;17(7):687-91. doi: 10.1007/BF00968006.