Díaz-Muñoz M, Hernández-Muñoz R, Suárez J, Chagoya de Sánchez V
Neuroscience. 1985 Dec;16(4):859-63. doi: 10.1016/0306-4522(85)90100-9.
Lipoperoxidation, glutathione cycle components and superoxide dismutase activity show a day-night rhythm in the cerebral cortex of the rat. The highest lipoperoxidative activity is observed during the night (20.00-04.00 h). The enhancement in lipoperoxidation occurs concurrently with a decrease in glutathione peroxidase activity, an increase in superoxide dismutase activity and an increase in the double bonds in the brain cortex lipid fraction. The changes described in this paper seem to be related to a succession of light and dark periods, or to fasting and feeding periods. We propose that those fluctuations could act as a physiological oscillator with an important role in modulating the membrane properties of the nerve cell.
脂质过氧化、谷胱甘肽循环成分和超氧化物歧化酶活性在大鼠大脑皮层呈现昼夜节律。在夜间（20:00 - 04:00）观察到最高的脂质过氧化活性。脂质过氧化的增强与谷胱甘肽过氧化物酶活性的降低、超氧化物歧化酶活性的增加以及大脑皮层脂质部分双键的增加同时发生。本文所述的变化似乎与明暗周期的交替或禁食与进食周期有关。我们认为这些波动可能作为一种生理振荡器，在调节神经细胞膜特性方面发挥重要作用。
