Robl J M, Thomford P J, Wu M C, Dziuk P J
Pediatr Pharmacol (New York). 1985;5(3):157-64.
Prepuberal female mice were treated with estradiol benzoate (EB), testosterone (T), or phenobarbital (PB), or were untreated. At 8 days after treatment treated mice had lower uterine weights than did untreated mice. Mice treated with EB and PB also had higher levels of hepatic cytochrome P450 at this time. The uteri of mice treated with EB, T, or PB were capable of responding to exogenous EB 8 days following the treatment with an increase in weight. In a second experiment mice were treated with a range of doses of EB, T, or PB,. At the lower doses there was an inverse association of uterine weight and cytochrome P450 levels. At higher doses there was no apparent association. These data indicate that uterine weight may be influenced in part by prior treatment that also affects the level of liver enzymes.
对青春期前的雌性小鼠用苯甲酸雌二醇（EB）、睾酮（T）或苯巴比妥（PB）进行处理，或不进行处理。处理后8天，接受处理的小鼠子宫重量低于未处理的小鼠。此时，用EB和PB处理的小鼠肝细胞色素P450水平也更高。用EB、T或PB处理的小鼠子宫在处理后8天能够对外源性EB作出反应，重量增加。在第二个实验中，用一系列剂量的EB、T或PB处理小鼠。在较低剂量时，子宫重量与细胞色素P450水平呈负相关。在较高剂量时，没有明显的相关性。这些数据表明，子宫重量可能部分受到先前处理的影响，而这种处理也会影响肝酶水平。
