Brechbühl Julien, Lopes Ana Catarina, Wood Dean, Sauge Elodie, Sidhom Marianne, Gilliand Noah, Nenniger Tosato Monique, Gachon Frédéric, Broillet Marie-Christine
Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, 1011 Lausanne, Switzerland.
Institute for Molecular Bioscience, the University of Queensland, St. Lucia, QLD, Australia.
iScience. 2025 Jul 24;28(8):113078. doi: 10.1016/j.isci.2025.113078. eCollection 2025 Aug 15.
The persistence of juvenile-like properties in specific cell types can provide adaptive advantages to stressful environments. In animals, such traits are well described at the organismal level, but their existence and regulation at the cellular level remain poorly understood. Here, using mice with genetically tagged mature olfactory sensory neurons (OSNs), we show that these neurons can retain immature features in response to environmental stress generated by an increased airflow. This delayed maturation is associated with the sustained nuclear expression of the activating transcription factor 5 (ATF5), which we found to be a potential regulator of this neuronal plasticity. In -deficient mice, this adaptive response fails to occur, leading to the subsequent loss of OSNs under environmental stress. Thus, the identified protective mechanism in the olfactory system may serve to safeguard neuronal integrity and ensure functional adaptation to environmental stress.
特定细胞类型中类幼态特性的持续存在可为应激环境提供适应性优势。在动物中，此类特征在机体水平上已有充分描述，但其在细胞水平上的存在及调控仍知之甚少。在此，我们利用基因标记成熟嗅觉感觉神经元（OSN）的小鼠，发现这些神经元能够响应气流增加所产生的环境应激而保留不成熟特征。这种成熟延迟与激活转录因子5（ATF5）的持续核表达相关，我们发现ATF5是这种神经元可塑性的潜在调节因子。在ATF5缺陷小鼠中，这种适应性反应无法发生，导致在环境应激下随后出现OSN丧失。因此，在嗅觉系统中确定的保护机制可能有助于维护神经元的完整性，并确保对环境应激的功能适应。
