Varghese Nidhy P, Ely Erin, Fombin Rozmeen, Champion Claire, Whalen Elise
Department of Pediatrics, Division of Pulmonology Baylor College of Medicine Houston Texas USA.
Texas Children's Hospital Pulmonary Hypertension Center at the Texas Medical Center Houston Texas USA.
Pulm Circ. 2025 Sep 12;15(3):e70158. doi: 10.1002/pul2.70158. eCollection 2025 Jul.
Adhesive reactions are common complications of continuous treprostinil infusions, limiting their recommended use as a treatment for severe pulmonary hypertension. We present the case of a 10-year-old male with recurrent adhesive-related skin reactions, which compromised both subcutaneous and intravenous continuous treatment. Due to comorbid atopic dermatitis (AD), dupilumab was initiated to decrease skin reactions to adhesives. Within 48 h of initiation, skin reactions completely resolved. With sustained dupilumab treatment, he remains symptom-free and is successfully tolerating intravenous treprostinil infusion.
黏附反应是持续输注曲前列尼尔常见的并发症，限制了其作为重度肺动脉高压治疗的推荐应用。我们报告了一例10岁男性患者，其反复出现与黏附相关的皮肤反应，这影响了皮下和静脉连续治疗。由于合并特应性皮炎（AD），开始使用度普利尤单抗以减少对黏附剂的皮肤反应。在开始治疗后的48小时内，皮肤反应完全消退。随着度普利尤单抗的持续治疗，他一直无症状，并且成功耐受静脉输注曲前列尼尔。
