Bal-Ozturk Ayça, Cecen Berivan, Avci-Adali Meltem, Topkaya Seda Nur, Alarcin Emine, Yasayan Gokcen, Ethan Yi-Chen, Bulkurcuoglu Bunyamin, Akpek Ali, Avci Huseyin, Shi Kun, Shin Su Ryon, Hassan Shabir
Department of Analytical Chemistry, Faculty of Pharmacy, Istinye University, 34010, Zeytinburnu, Istanbul, Turkey.
Department of Stem Cell and Tissue Engineering, Institute of Health Sciences, Istinye University, 34010 Istanbul, Turkey.
Nano Today. 2021 Feb;36. doi: 10.1016/j.nantod.2020.101049. Epub 2020 Dec 20.
Sutures, staples, clips and skin closure strips are used as the gold standard to close wounds after an injury. In spite of being the present standard of care, the utilization of these conventional methods is precarious amid complicated and sensitive surgeries such as vascular anastomosis, ocular surgeries, nerve repair, or due to the high-risk components included. Tissue adhesives function as an interface to connect the surfaces of wound edges and prevent them from separation. They are fluid or semi-fluid mixtures that can be easily used to seal any wound of any morphology - uniform or irregular. As such, they provide alternatives to new and novel platforms for wound closure methods. In this review, we offer a background on the improvement of distinctive tissue adhesives focusing on the chemistry of some of these products that have been a commercial success from the clinical application perspective. This review is aimed to provide a guide toward innovation of tissue bioadhesive materials and their associated biomedical applications.
缝线、吻合钉、夹子和皮肤闭合条被用作受伤后伤口闭合的金标准。尽管这些是当前的护理标准，但在诸如血管吻合、眼科手术、神经修复等复杂且敏感的手术中，或者由于包含高风险因素，使用这些传统方法存在风险。组织粘合剂作为连接伤口边缘表面并防止其分离的界面。它们是流体或半流体混合物，可轻松用于密封任何形态（均匀或不规则）的伤口。因此，它们为伤口闭合方法的新平台提供了替代方案。在本综述中，我们提供了关于独特组织粘合剂改进的背景知识，重点关注从临床应用角度来看已取得商业成功的一些此类产品的化学性质。本综述旨在为组织生物粘附材料及其相关生物医学应用的创新提供指导。
