Raheem Abdul, Khan Ilyas, Ahmad Iqbal, Wajid Abdul, Alshahrani Mohammad Y, Alzahrani Fuad M, Alzahrani Khalid J, Qadeer Abdul, Liao I-Chuang, Chen Chien-Chin
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
Front Immunol. 2025 Aug 29;16:1640113. doi: 10.3389/fimmu.2025.1640113. eCollection 2025.
Regulatory T cells (Tregs) are a unique subset of T cells vital for maintaining immune balance, preventing autoimmune diseases, and controlling immune responses. First identified in the early 1990s, Tregs are now well recognized for their role in suppressing excessive immune reactions and promoting tolerance to the body's tissues. Among the broader Treg population, Tissue regulatory T cells (Tissue Tregs) are distinct as they do more than suppress immunity; they actively contribute to tissue repair and regeneration. Studies in both mice and humans have highlighted the important role of in aiding tissue repair and maintaining tissue integrity. Recent research reveals that Tregs participate in wound healing and tissue regeneration across various organs, including the heart, liver, kidneys, muscles, lungs, bones, and central nervous system. These discoveries emphasize the wide-ranging and significant influence of Tregs in fostering recovery and healing in different tissues throughout the body. These cells are characterized by their ability to produce a variety of growth factors, cytokines, and signaling molecules that support the repair and regeneration of damaged tissues. In this review, we present an overview of the emerging understanding of Treg-mediated repair processes in damaged tissues and organs.
调节性T细胞（Tregs）是T细胞的一个独特亚群，对于维持免疫平衡、预防自身免疫性疾病以及控制免疫反应至关重要。Tregs于20世纪90年代初首次被发现，如今因其在抑制过度免疫反应和促进机体对自身组织的耐受性方面的作用而广为人知。在更广泛的Treg群体中，组织调节性T细胞（组织Tregs）与众不同，因为它们不仅抑制免疫，还积极参与组织修复和再生。对小鼠和人类的研究都突出了其在协助组织修复和维持组织完整性方面的重要作用。最近的研究表明，Tregs参与包括心脏、肝脏、肾脏、肌肉、肺、骨骼和中枢神经系统在内的各个器官的伤口愈合和组织再生。这些发现强调了Tregs在促进全身不同组织的恢复和愈合方面具有广泛而重大的影响。这些细胞的特点是能够产生多种支持受损组织修复和再生的生长因子、细胞因子和信号分子。在这篇综述中，我们概述了对Treg介导的受损组织和器官修复过程的新认识。
