Wu Han, Yang Xue-Ying, Liang Chao-Qun, Yang Jian-Ming
Department of Otolaryngology Head and Neck Surgery, Second Hospital of Anhui Medical University, Hefei, China.
Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Soochow University, Suzhou, China.
Front Neurosci. 2025 Aug 29;19:1647513. doi: 10.3389/fnins.2025.1647513. eCollection 2025.
Age and duration of deafness significantly affect the auditory nerve (AN) health of cochlear implant (CI) users. In this study, we examine how age and duration of deafness impact Electrically Evoked Compound Action Potential (ECAP) amplitudes when the Inter-Pulse Interval (IPI) parameter in ECAP measurements is varied.
Our participants were thirty-one Mandarin-speaking CI users with Nurotron/CS-20A (19 males and 12 females, 33 ears, aged 6-66 yrs). We investigated eleven distinct IPI settings, ranging from 290 μs to 590 μs (IPI = 290, 330, 350, 390, 410, 450, 470, 510, 530, 570, 590 μs).
The first result of our study was to find the optimal IPI of the participants. Furthermore, the optimal IPI was positively correlated with both the age of the participants ( = 0.6018, = 0.0002) and the duration of deafness ( = 0.3479, = 0.0473).
Our study sheds light on the pivotal role of age and duration of deafness in ECAP amplitudes and optimizing IPI settings. We recommend that CI users with advanced age and long duration of deafness use longer IPI parameters for ECAP measurements to obtain a more accurate ECAP waveform. These insights hold significant implications for tailoring CI programming and rehabilitation strategies to cater to the distinct needs of individuals across different ages and duration of deafness groups, ultimately enhancing the auditory experiences and outcomes of CI users.
年龄和耳聋持续时间会显著影响人工耳蜗（CI）使用者的听神经（AN）健康。在本研究中，我们探究了在电诱发复合动作电位（ECAP）测量中，当脉冲间隔（IPI）参数变化时，年龄和耳聋持续时间如何影响ECAP振幅。
我们的参与者是31名说普通话的Nurotron/CS - 20A人工耳蜗使用者（19名男性和12名女性，33只耳朵，年龄6 - 66岁）。我们研究了11种不同的IPI设置，范围从290微秒到590微秒（IPI = 290、330、350、390、410、450、470、510、530、570、590微秒）。
我们研究的第一个结果是找出参与者的最佳IPI。此外，最佳IPI与参与者的年龄（r = 0.6018，p = 0.0002）和耳聋持续时间（r = 0.3479，p = 0.0473）均呈正相关。
我们的研究揭示了年龄和耳聋持续时间在ECAP振幅以及优化IPI设置方面的关键作用。我们建议年龄较大且耳聋持续时间较长的人工耳蜗使用者在进行ECAP测量时使用更长的IPI参数，以获得更准确的ECAP波形。这些见解对于调整人工耳蜗编程和康复策略以满足不同年龄和耳聋持续时间组个体的独特需求具有重要意义，最终可提升人工耳蜗使用者的听觉体验和效果。
