Shibahara Keigo, Hayashi Koichiro, Nakashima Yasuharu, Ishikawa Kunio
Department of Biomaterials Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
ACS Omega. 2025 Aug 25;10(35):39494-39503. doi: 10.1021/acsomega.4c11634. eCollection 2025 Sep 9.
Segmental bone defects often present as new irregularly growing bones that fail to bridge gaps. Optimizing the scaffold design for direct bone growth can enhance bone defect reconstruction. We evaluated three carbonate apatite honeycomb-structured scaffolds with uniaxial macropores of 280, 440, and 640 μm (labeled P280, P440, and P640, respectively) implanted into critical-sized ulnar defects in rabbits. The scaffold performance was assessed at 4 and 12 weeks postimplantation. P280 formed small volumes of oriented bone, which decreased the bone strength. P440 formed large volumes of oriented bone and restored bone strength. Meanwhile, P640 formed abundant volumes of disorganized bone and failed to enhance bone strength. The 440 μm macropores effectively guided new bone and enhanced the bone strength. These findings suggest that the macropore size is crucial for designing scaffolds for effective segmental bone defect reconstruction.
节段性骨缺损常表现为新生成的不规则生长的骨头，无法桥接骨间隙。优化用于直接骨生长的支架设计可增强骨缺损修复。我们评估了三种具有280、440和640μm单轴大孔的碳酸盐磷灰石蜂窝结构支架（分别标记为P280、P440和P640），将其植入兔的临界尺寸尺骨缺损处。在植入后4周和12周评估支架性能。P280形成少量定向骨，降低了骨强度。P440形成大量定向骨并恢复了骨强度。同时，P640形成大量杂乱无章的骨，未能增强骨强度。440μm的大孔有效地引导了新骨生长并增强了骨强度。这些发现表明，大孔尺寸对于设计用于有效节段性骨缺损修复的支架至关重要。
