Mancini A F, Rosito P, Capucci M C, Bousi S, Lucchi A, Tani G, Galassi E, Putti C, Mancuso A
Pediatr Med Chir. 1985 Mar-Apr;7(2):305-10.
Clinical-radiological findings, treatment and prognosis of cranial involvement in 19 cases of neuroblastoma stage IV have been considered. The most frequent clinical features were periorbital ecchymosis and intracranial hypertension. The radiographic aspects, graduated according to the type of the lesion, showed a close correlation with clinical findings and sometimes preceded them. Computerized tomography, carried out in 12 cases, was more reliable than plain films in identifying the site and extent of cranial lesions and the presence of cerebral extensions, as occurred in 2 patients. The presence of cranial involvement at diagnosis was an unfavorable prognostic sign. The 19 children were treated in various ways so that firm conclusions cannot be drawn, but cranial radiotherapy in combination with chemotherapy appeared to be more efficacious than chemotherapy alone.
已对19例IV期神经母细胞瘤患者颅骨受累的临床放射学表现、治疗及预后进行了研究。最常见的临床特征为眶周瘀斑和颅内高压。根据病变类型分级的影像学表现与临床发现密切相关，有时还早于临床发现。12例患者进行了计算机断层扫描，在确定颅骨病变的部位和范围以及脑转移情况方面，计算机断层扫描比平片更可靠，有2例患者出现了脑转移。诊断时颅骨受累是一个不良预后征象。19名儿童接受了多种治疗，因此无法得出确切结论，但颅骨放疗联合化疗似乎比单纯化疗更有效。
