Ota Junya, Matsunaga Masaaki, Haga Fuminori, Suzumura Ayana, Yamada Kazuhisa, Shimizu Hideyuki, Kachi Shu, Ota Ichiro, Miyake Goichiro, Mokuno Kumiko, Inooka Daiki, Iwata Emi, Akahori Tomohiko, Nishiguchi Koji M, Kaneko Hiroki
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Ophthalmology, Nishio Municipal Hospital, Nishio, Japan.
Clin Ophthalmol. 2025 Sep 6;19:3283-3293. doi: 10.2147/OPTH.S541269. eCollection 2025.
Tecnis Eyhance (DIB00V) is a type of monofocal intraocular lens (IOL) categorized as "IOL-plus", a new concept developed to improve not only distance but also intermediate vision. However, its negative effect, eg difficulty in macular surgery that is occasionally seen with the multifocal IOL, has not been ruled out in combined surgery for epiretinal membrane (ERM) and cataracts. This study aimed to compare DIB00V with a conventional monofocal IOL (DCB00V) in terms of visual acuity and patient-reported outcomes of combined surgery for epiretinal membrane (ERM) and cataracts.
This was a multicenter, prospective, nonrandomized, observational study conducted in Japan. Patients scheduled for combined cataract and pars plana vitrectomy (PPV) for cataract and ERM were enrolled. IOL was selected according to the rules originally applied in each facility. Best-corrected distance visual acuity (BCDVA) and distance-corrected intermediate visual acuity (DCIVA) at 3-month visits postoperatively, surgical parameters, and Japanese-modified Catquest-9SF Questionnaire scores were compared between the two IOL groups.
Sixty-two eyes implanted with DCB00V (Tecnis-1) and 79 eyes implanted with DIB00V (Eyhance) were analyzed. There was no significant difference in BCDVA with Eyhance (0.09 in logMAR) and Tecnis-1 (0.05 in logMAR, = 0.174), and DCIVA with Eyhance (0.35 in logMAR) and Tecnis-1 (0.39 in logMAR, = 0.200). Rasch analysis of the Japanese-modified Catquest-9SF Questionnaire revealed that Eyhance scored higher in patients' general satisfaction ( = 0.0269). Subgroup analysis revealed a better postoperative distance-corrected intermediate visual acuity in patients with a certain degree of preoperative myopia (spherical error < -1.5 diopter).
Eyhance provided comparable postoperative visual acuity to the conventional monofocal IOL in combined surgery for cataract and ERM, and surgical parameters are not different in the two types of IOL. Furthermore, Eyhance improved postoperative satisfaction in the overall population and significantly improved intermediate visual acuity in the preoperatively myopic population.
Tecnis Eyhance（DIB00V）是一种单焦点人工晶状体（IOL），属于“增强型IOL”类别，这是一个旨在不仅改善远视力而且改善中视力而开发的新概念。然而，在视网膜前膜（ERM）和白内障联合手术中，尚未排除其负面影响，例如多焦点IOL偶尔出现的黄斑手术困难。本研究旨在比较DIB00V与传统单焦点IOL（DCB00V）在视网膜前膜（ERM）和白内障联合手术中的视力及患者报告的结局。
这是一项在日本进行的多中心、前瞻性、非随机观察性研究。纳入计划进行白内障和ERM的白内障联合玻璃体切割术（PPV）的患者。根据各机构原来适用的规则选择IOL。比较两组IOL术后3个月随访时的最佳矫正远视力（BCDVA）和距离矫正中视力（DCIVA）、手术参数以及日本版改良Catquest-9SF问卷评分。
分析了62只植入DCB00V（Tecnis-1）的眼和79只植入DIB00V（Eyhance）的眼。Eyhance组的BCDVA（logMAR为0.09）与Tecnis-1组（logMAR为0.05，P = 0.174）无显著差异，Eyhance组的DCIVA（logMAR为0.35）与Tecnis-1组（logMAR为0.39，P = 0.200）也无显著差异。对日本版改良Catquest-9SF问卷的Rasch分析显示，Eyhance在患者总体满意度方面得分更高（P = 0.0269）。亚组分析显示，术前有一定程度近视（球镜度数＜-1.5屈光度）的患者术后距离矫正中视力更好。
在白内障和ERM联合手术中，Eyhance术后视力与传统单焦点IOL相当，两种IOL的手术参数无差异。此外，Eyhance提高了总体人群的术后满意度，并显著改善了术前近视人群的中视力。
