Perkins Guy A, Guiducci Silvia, Res Giulia, Savio Federica, Trevisanuto Daniele, Priante Elena, Baraldi Eugenio, Galderisi Alfonso, Brigadoi Sabrina
Department of Developmental Psychology and Socialization, University of Padova, Via Venezia, 8, 35131, Padova, Italy.
Department of Women' and Children's Health, University of Padova, Via Giustiniani, 3, 35128, Padova, Italy.
medRxiv. 2025 Sep 2:2025.09.01.25334829. doi: 10.1101/2025.09.01.25334829.
Very preterm neonates are more prone to experience hyper and hypo-glycaemia after birth. To date, there is no available evidence on the local brain hemodynamic response to these glycemic changes. This study uses continuous glucose monitoring (CGM) and diffuse optical tomography (DOT) to investigate this issue. Sixty very preterm neonates were recruited and continuously monitored after birth with CGM and DOT for several days. Patients with only mild (Sensor glucose concentration (SGC) ≥ 48 mg/dL & ≤ 72 mg/dL) or severe (SGC ≤ 47 mg/dL) hypoglycaemia (N=17) were then selected for analysis. DOT data were reconstructed in three 10-minute windows throughout each hypoglycemic event: at the beginning of the event, after the minimum of hypoglycemia, and at the end of the event. Correlations and spatial consistencies were found between changes in blood volume and SGC during these time windows, suggesting a coupling between SGC and brain hemodynamics in very preterm newborns after birth.
极早产儿出生后更易出现高血糖和低血糖。迄今为止，尚无关于局部脑血流动力学对这些血糖变化反应的可用证据。本研究采用连续血糖监测（CGM）和扩散光学断层扫描（DOT）来研究这个问题。招募了60名极早产儿，出生后用CGM和DOT连续监测数天。然后选择仅患有轻度（传感器葡萄糖浓度（SGC）≥48mg/dL且≤72mg/dL）或重度（SGC≤47mg/dL）低血糖的患者（N = 17）进行分析。在每个低血糖事件的三个10分钟时间段内重建DOT数据：事件开始时、低血糖最低值之后以及事件结束时。在这些时间段内发现血容量变化与SGC之间存在相关性和空间一致性，这表明极早产儿出生后SGC与脑血流动力学之间存在耦合。
