Wang Kunchun, Li Zhenbo, Shen Shengnan, Wang Lei, Wang Huizheng, Li Delong
Agricultural Technology Service Center of Linzi District, Zibo, China.
Shandong Agricultural Technology Extension Service Center, Jinan, China.
Front Microbiol. 2025 Aug 29;16:1600831. doi: 10.3389/fmicb.2025.1600831. eCollection 2025.
, a necrotrophic phytopathogen responsible for gray mold disease, poses a significant threat to global postharvest horticultural production due to substantial spoilage of fruits and vegetables. This study systematically investigated the antifungal efficacy and molecular mechanisms of terpinen-4-ol against Terpinen-4-ol exhibited a broad-spectrum of antifungal activity, significantly inhibiting both mycelium growth and conidial viability of . Further analyses revealed that terpinen-4-ol disrupted cell membrane integrity and induced reactive oxygen species (ROS) accumulation. The inhibitory effect may be attributed to its ability to promote ROS accumulation and induce autophagy activity, thereby disrupting the intracellular redox balance and autophagic processes in fungi, ultimately leading to apoptosis via a metacaspase-dependent pathway. Altogether, these findings revealed a specific antifungal mechanism of terpinen-4-ol against , suggesting its potential as an effective preservative for postharvest preservation of fruits.
一种导致灰霉病的坏死营养型植物病原体，由于水果和蔬菜的大量腐烂，对全球采后园艺生产构成重大威胁。本研究系统地研究了萜品-4-醇对[病原体名称未完整给出]的抗真菌效果和分子机制。萜品-4-醇表现出广谱的抗真菌活性，显著抑制[病原体名称未完整给出]的菌丝生长和分生孢子活力。进一步分析表明，萜品-4-醇破坏细胞膜完整性并诱导活性氧（ROS）积累。其抑制作用可能归因于它促进ROS积累和诱导自噬活性的能力，从而破坏真菌细胞内的氧化还原平衡和自噬过程，最终通过一条依赖metacaspase的途径导致细胞凋亡。总之，这些发现揭示了萜品-4-醇对[病原体名称未完整给出]的特定抗真菌机制，表明其作为水果采后保鲜有效防腐剂的潜力。
