Pavan Kunhimoole Keshava, Vasudev Raghunath Bangalore, Radhakrishna Veerabhadra, Shenoy Hejmady Aneesh, Karthik Shivaram Anusuya
Department of Pediatric Surgery, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
J Indian Assoc Pediatr Surg. 2025 Sep-Oct;30(5):589-594. doi: 10.4103/jiaps.jiaps_85_25. Epub 2025 May 21.
The aim of the study was to evaluate the role of pancreatic divisum (PD) in children with pancreatitis.
A retrospective observational study was conducted at a pediatric surgery tertiary center which included children aged <18 years who presented with pancreatitis between January 2013 and June 2024. The children with pancreatitis having PD (PD pancreatitis group) were compared to the children with pancreatitis not having PD (non-PD pancreatitis group).
A total of 275 children with pancreatitis were included in the study and 15 (5.5%) of them had PD. Type 1 (Classical) PD was seen in 11 (69%) of the children and nine (60%) children presented with acute recurrent pancreatitis (ARP). The children with PD pancreatitis presented at a younger age (9.8 ± 4.3 years vs. 12.2 ± 3.7 years; = 0.02; independent sample -test) and tend to have a significantly higher incidence of ARP (9 [60%] vs. 58 [22%]; < 0.001; Chi-square test) compared to the children with non-PD pancreatitis.
Children with PD present at a younger age with pancreatitis and are at increased risk of developing ARP. This suggests that PD is an independent etiology for developing pancreatitis in children.
本研究旨在评估胰腺分裂症(PD)在儿童胰腺炎中的作用。
在一家儿科外科三级中心进行了一项回顾性观察研究,纳入了2013年1月至2024年6月期间出现胰腺炎的18岁以下儿童。将患有PD的胰腺炎儿童(PD胰腺炎组)与未患有PD的胰腺炎儿童(非PD胰腺炎组)进行比较。
本研究共纳入275例胰腺炎儿童,其中15例(5.5%)患有PD。11例(69%)儿童为1型(经典型)PD,9例(60%)儿童表现为急性复发性胰腺炎(ARP)。与非PD胰腺炎儿童相比,PD胰腺炎儿童发病年龄更小(9.8±4.3岁对12.2±3.7岁;P = 0.02;独立样本t检验),且ARP发病率显著更高(9例[60%]对58例[22%];P < 0.001;卡方检验)。
患有PD的儿童胰腺炎发病年龄较小,发生ARP的风险增加。这表明PD是儿童胰腺炎发病的一个独立病因。