SHOX-2甲基化检测对恶性胸腔积液的诊断准确性：一项系统评价和荟萃分析
Diagnostic accuracy of SHOX-2 methylation for malignant pleural effusion: a systematic review and meta-analysis.
作者信息
Wang Hao-Jie, Cui Jian-Ying, Hou Wen-Jie, Hao Xu-Lei, Zheng Wen-Qi, Hu Zhi-De, Cao Xi-Shan, Yan Li
机构信息
Department of Respiratory and Critical Care Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Key Laboratory for Biomarkers, Inner Mongolia Medical University, Hohhot, China.
出版信息
Transl Cancer Res. 2025 Aug 31;14(8):4955-4964. doi: 10.21037/tcr-2025-686. Epub 2025 Aug 19.
BACKGROUND
Some studies have assessed the diagnostic value of SHOX-2 methylation for malignant pleural effusion (MPE), but their findings were inconsistent. This study aimed to conduct a systematic review and meta-analysis to evaluate the diagnostic accuracy of SHOX-2 methylation for MPE.
METHODS
We searched the PubMed and Web of Science databases to identify studies involving SHOX-2 methylation in diagnosing MPE. The last search date was in December 2024. We evaluated the quality of the included studies using the revised Quality Assessment of Diagnostic Accuracy Studies tool-2 (QUADAS-2). A bivariate model was used to pool the sensitivity, specificity, and their 95% confidence intervals (CIs) of SHOX-2 methylation. The overall diagnostic accuracy of SHOX-2 methylation was assessed by a summary receiver operating characteristic (sROC) curve. The publication bias was analyzed using Deek's test.
RESULTS
Six studies with 613 MPE patients and 723 benign pleural effusion (BPE) patients were included. The pooled sensitivity (95% CI) and specificity (95% CI) of SHOX-2 methylation were 0.64 (0.36-0.85) and 0.96 (0.92-0.98), respectively. The area under the sROC curve was 0.96 (95% CI: 0.94-0.97). There was no publication bias across the eligible studies.
CONCLUSIONS
SHOX-2 methylation has a moderate diagnostic value for MPE.
背景
一些研究评估了SHOX-2甲基化对恶性胸腔积液（MPE）的诊断价值，但其结果并不一致。本研究旨在进行系统评价和荟萃分析，以评估SHOX-2甲基化对MPE的诊断准确性。
方法
我们检索了PubMed和Web of Science数据库，以识别涉及SHOX-2甲基化诊断MPE的研究。最后一次检索日期为2024年12月。我们使用修订后的诊断准确性研究质量评估工具-2（QUADAS-2）评估纳入研究的质量。采用双变量模型汇总SHOX-2甲基化的敏感性、特异性及其95%置信区间（CI）。通过汇总受试者工作特征（sROC）曲线评估SHOX-2甲基化的总体诊断准确性。使用Deek检验分析发表偏倚。
结果
纳入了6项研究，共613例MPE患者和723例良性胸腔积液（BPE）患者。SHOX-2甲基化的合并敏感性（95%CI）和特异性（95%CI）分别为0.64（0.36-0.85）和0.96（0.92-0.98）。sROC曲线下面积为0.96（95%CI：0.94-0.97）。在符合条件的研究中没有发表偏倚。
结论
SHOX-2甲基化对MPE具有中等诊断价值。
Zotero 插件