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Dual roles of mTOR in skeletal muscle adaptation: coordinating hypertrophic and mitochondrial biogenesis pathways for exercise-induced chronic disease management.

作者信息

Zhao Yong-Cai

机构信息

Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, College of Exercise and Health, Tianjin University of Sport, Tianjin, China.

出版信息

Front Med (Lausanne). 2025 Aug 29;12:1635219. doi: 10.3389/fmed.2025.1635219. eCollection 2025.

DOI:10.3389/fmed.2025.1635219
PMID:40950953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12426163/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5804/12426163/39889af9cdd7/fmed-12-1635219-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5804/12426163/39889af9cdd7/fmed-12-1635219-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5804/12426163/39889af9cdd7/fmed-12-1635219-g0001.jpg

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本文引用的文献

1
Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway.玉竹多糖通过PI3K/Akt/mTOR信号通路改善骨骼肌衰老和线粒体功能障碍。
Phytomedicine. 2025 Jan;136:156316. doi: 10.1016/j.phymed.2024.156316. Epub 2024 Dec 9.
2
Arginine Regulates Skeletal Muscle Fiber Type Formation via mTOR Signaling Pathway.精氨酸通过 mTOR 信号通路调节骨骼肌纤维类型形成。
Int J Mol Sci. 2024 Jun 4;25(11):6184. doi: 10.3390/ijms25116184.
3
Ashwagandha Ethanol Extract Attenuates Sarcopenia-Related Muscle Atrophy in Aged Mice.
印度人参乙醇提取物可减轻老龄小鼠与肌肉减少症相关的肌肉萎缩。
Nutrients. 2024 Jan 3;16(1):157. doi: 10.3390/nu16010157.
4
Different Resistance Exercise Loading Paradigms Similarly Affect Skeletal Muscle Gene Expression Patterns of Myostatin-Related Targets and mTORC1 Signaling Markers.不同的抗阻运动负荷范式同样影响肌肉生长抑制素相关靶点和 mTORC1 信号标记物的骨骼肌基因表达模式。
Cells. 2023 Mar 15;12(6):898. doi: 10.3390/cells12060898.
5
The role of the mechanistic target of rapamycin complex 1 in the regulation of mitochondrial adaptation during skeletal muscle atrophy under denervation or calorie restriction in mice.雷帕霉素复合物1的机制性靶点在小鼠去神经支配或热量限制引起的骨骼肌萎缩过程中线粒体适应性调节中的作用。
Appl Physiol Nutr Metab. 2023 Mar 1;48(3):241-255. doi: 10.1139/apnm-2022-0336. Epub 2023 Feb 14.
6
The Importance of mTORC1-Autophagy Axis for Skeletal Muscle Diseases.mTORC1-自噬轴在肌肉骨骼疾病中的重要性。
Int J Mol Sci. 2022 Dec 24;24(1):297. doi: 10.3390/ijms24010297.
7
Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity.eIF4E 结合蛋白 1 的激活通过扩大溶酶体降解能力来挽救 mTORC1 诱导的肌肉减少症。
J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):198-213. doi: 10.1002/jcsm.13121. Epub 2022 Nov 17.
8
Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function.单磷酸腺苷激活蛋白激酶通过控制线粒体功能来促进骨骼肌健康。
Front Pharmacol. 2022 Oct 20;13:947387. doi: 10.3389/fphar.2022.947387. eCollection 2022.
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Endoplasmic reticulum stress downregulates PGC-1α in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2.内质网应激通过激活转录因子4（ATF4）以及哺乳动物雷帕霉素靶蛋白（mTOR）介导的含CREB调节蛋白2（CRTC2）减少，下调骨骼肌中的过氧化物酶体增殖物激活受体γ辅助激活因子1α（PGC-1α）。
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