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痤疮瘢痕治疗进展

Advances in the treatment of acne scars.

作者信息

Zhang Meng, Liu Chunmei, Zhang Shengni, Chu Ruiqi, Ren Xiangxiang

机构信息

Department of Dermatology, Affiliated Hospital of Hebei University, Baoding, Hebei, China.

Affiliated Hospital of Hebei University, Baoding, Hebei, China.

出版信息

Front Med (Lausanne). 2025 Aug 29;12:1643035. doi: 10.3389/fmed.2025.1643035. eCollection 2025.

DOI:10.3389/fmed.2025.1643035
PMID:40950966
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12425707/
Abstract

Acne vulgaris and its resulting scars represent common clinical dermatological concerns. Even after the resolution of active lesions, scars can cause significant psychological distress and severely impair patients' quality of life. In recent years, advancements in medical technology have led to the clinical application of various innovative therapies for acne scar management, with the primary goals of effectively improving both the aesthetic appearance and functionality of the scars. Treatment strategies continue to be refined-ranging from traditional physical modalities (such as microneedling) to modern energy-based devices (such as fractional lasers)-to balance efficacy and safety. Current research focuses on developing combination therapy approaches. The integration of chemical peels, laser technologies, and dermal fillers is emerging as a key trend for the future, aiming to enhance treatment outcomes while reducing treatment burden.

摘要

寻常痤疮及其所致疤痕是常见的临床皮肤科问题。即使活动性皮损消退后,疤痕仍可导致严重的心理困扰,并严重损害患者的生活质量。近年来,医疗技术的进步促使各种创新疗法在痤疮疤痕管理中得到临床应用,其主要目标是有效改善疤痕的美观外观和功能。治疗策略不断完善,从传统的物理方法(如微针疗法)到现代的能量型设备(如分次激光),以平衡疗效和安全性。当前的研究重点是开发联合治疗方法。化学剥脱、激光技术和真皮填充剂的联合应用正成为未来的一个关键趋势,旨在提高治疗效果,同时减轻治疗负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/754c/12425707/a3ae100628ec/fmed-12-1643035-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/754c/12425707/3bedc93fe9b1/fmed-12-1643035-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/754c/12425707/a3ae100628ec/fmed-12-1643035-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/754c/12425707/3bedc93fe9b1/fmed-12-1643035-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/754c/12425707/a3ae100628ec/fmed-12-1643035-g0002.jpg

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本文引用的文献

1
Dose-Dependent Effects of Cross-Linked Hyaluronic Acid Through Intradermal Injection on Female Facial Photoaging: A Prospective Study.交联透明质酸皮内注射对女性面部光老化的剂量依赖性效应:一项前瞻性研究。
Aesthet Surg J Open Forum. 2025 May 27;7:ojaf046. doi: 10.1093/asjof/ojaf046. eCollection 2025.
2
Poly-d,l-lactic Acid (PDLLA) Application in Dermatology: A Literature Review.聚-d,l-乳酸(PDLLA)在皮肤科的应用:文献综述
Polymers (Basel). 2024 Sep 13;16(18):2583. doi: 10.3390/polym16182583.
3
Treatment of Acne Scars with Microneedling and Chemical Reconstruction of Scarred Skin Therapy (CROSS) Using Penol/Croton Oil Combination.
微针和化学重建瘢痕皮肤疗法(CROSS)联合使用苯酚/巴豆油治疗痤疮瘢痕。
J Drugs Dermatol. 2024 Jun 1;23(6):418-422. doi: 10.36849/JDD.7657.
4
Calcium Hydroxylapatite (CaHA) and Aesthetic Outcomes: A Systematic Review of Controlled Clinical Trials.羟基磷灰石钙(CaHA)与美学效果:对照临床试验的系统评价
J Clin Med. 2024 Mar 14;13(6):1686. doi: 10.3390/jcm13061686.
5
Autologous Nanofat Injection Combined with Fractional CO2 Laser in the Treatment of Atrophic Acne Scars.自体纳米脂肪注射联合二氧化碳点阵激光治疗萎缩性痤疮瘢痕
Clin Cosmet Investig Dermatol. 2024 Mar 20;17:697-705. doi: 10.2147/CCID.S454514. eCollection 2024.
6
Cosmetic therapies for Chinese patients with acne taking concomitant or recent intake of oral isotretinoin: A retrospective study.针对正在服用或近期服用过口服异维甲酸的中国痤疮患者的美容疗法:一项回顾性研究。
J Cosmet Dermatol. 2023 Nov;22(11):3168-3175. doi: 10.1111/jocd.15897. Epub 2023 Aug 17.
7
A Split-Face Study to Evaluate Efficacy of Autologous Injectable Platelet-Rich Fibrin With Microneedling Against Microneedling With Normal Saline (Placebo Control) in Atrophic Acne Scars.一项评价自体注射富血小板纤维蛋白联合微针与单纯微针对萎缩性痤疮瘢痕疗效的自身对照研究。
Dermatol Surg. 2023 Oct 1;49(10):938-942. doi: 10.1097/DSS.0000000000003893. Epub 2023 Aug 10.
8
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J Cosmet Dermatol. 2023 Nov;22(11):3008-3016. doi: 10.1111/jocd.15935. Epub 2023 Jul 18.
9
Atrophic acne scars, including scars less than 1.5 mm, may undergo spontaneous regression: A cohort study.萎缩性痤疮瘢痕,包括小于1.5毫米的瘢痕,可能会自发消退:一项队列研究。
JAAD Int. 2023 May 26;12:160-161. doi: 10.1016/j.jdin.2023.05.007. eCollection 2023 Sep.
10
"Multiple Mode Procedures" of Ultra-Pulse Fractional CO Laser: A Novel Treatment Modality of Facial Atrophic Acne Scars.超脉冲分数二氧化碳激光的“多模式治疗程序”:面部萎缩性痤疮瘢痕的一种新型治疗方式
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