Zhou Chenxi, Chen Weiliang, Zhang Liyuan, Luo Xiao, Zhu Lin, Zhang Erting, Li Kai, Qin Xiaolei
DEXI Clinc, DE YI Skin, Xi'an, Shanxi, China.
DEYUE Clinc, DE YI Skin, Shenzhen, China.
J Cosmet Dermatol. 2025 Jun;24(6):e70271. doi: 10.1111/jocd.70271.
The treatment of acne scars has always been challenging. In the past, its gold standard treatment was carbon dioxide (CO) fractional laser, but its efficacy rate was only 51%-70%. The use of poly-L-lactic acid (PLLA) has provided a new treatment strategy. In this study, a novel PLLA material was used in combination with a CO fractional laser to treat acne scars, and its safety and effectiveness were evaluated.
To determine the safety and effectiveness of PLLA (Loviselle) combined with a CO fractional laser in the treatment of acne scars.
In this study, 60 patients were randomly divided into two groups, with 30 patients in each group. Group A received only CO fractional laser treatment, whereas Group B received injections of PLLA 1, 3, and 5 months after CO fractional laser treatment. Both groups were followed up for 6 months after the CO fractional laser treatment.
There were statistically significant differences in the Quantitative Global Scarring Grading System (GSS) scores between the two groups before and after treatment. Group B had lower GSS scores than Group A. In the treatment of different types of acne scars using the Acne Scar Rating Scale, the improvement in rolling scars was greater than that in boxcar scars, and both were greater than those in ice-pick scars. Whether evaluated by independent physicians' assessment of treatment improvement or patients' satisfaction questionnaire, the combined treatment group showed better results than the single treatment group, and there were statistically significant differences between the two groups. Adverse reactions included transient redness, bruising, and pigmentation.
The combination of CO fractional laser and PLLA can safely and effectively treat acne scars, especially rolling and boxcar depressed scars.
痤疮瘢痕的治疗一直具有挑战性。过去，其金标准治疗方法是二氧化碳（CO）分次激光，但有效率仅为51%-70%。聚左旋乳酸（PLLA）的使用提供了一种新的治疗策略。在本研究中，一种新型PLLA材料与CO分次激光联合用于治疗痤疮瘢痕，并对其安全性和有效性进行评估。
确定PLLA（洛维塞尔）联合CO分次激光治疗痤疮瘢痕的安全性和有效性。
本研究中，60例患者随机分为两组，每组30例。A组仅接受CO分次激光治疗，而B组在CO分次激光治疗后1、3和5个月接受PLLA注射。两组在CO分次激光治疗后均随访6个月。
两组治疗前后的定量整体瘢痕分级系统（GSS）评分存在统计学显著差异。B组的GSS评分低于A组。使用痤疮瘢痕评定量表治疗不同类型的痤疮瘢痕时，滚轮状瘢痕的改善大于箱车型瘢痕，且两者均大于冰锥样瘢痕。无论是通过独立医生对治疗改善的评估还是患者满意度问卷进行评估，联合治疗组均显示出比单一治疗组更好的结果，两组之间存在统计学显著差异。不良反应包括短暂的发红、瘀斑和色素沉着。
CO分次激光与PLLA联合可安全有效地治疗痤疮瘢痕，尤其是滚轮状和箱车型凹陷性瘢痕。
