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暴发性脑膜炎球菌性休克:B群脑膜炎球菌的可怕面目

Meningococcal Septic Shock Revealed: The Frightening Face of Serogroup B.

作者信息

Inceli Belkis Hatice, Penezoglu Döndü Nilay, Havan Merve, Otgun Selin Nar, Evren Ebru, Karahan Zeynep Ceren, Kendirli Tanıl, Özdemir Halil, Çiftçi Ergin

机构信息

Pediatric Infectious Diseases, Ankara University School of Medicine, Ankara, TUR.

Infectious Disease, Ankara University School of Medicine, Ankara, TUR.

出版信息

Cureus. 2025 Aug 12;17(8):e89950. doi: 10.7759/cureus.89950. eCollection 2025 Aug.

Abstract

Meningococcal infections are still a serious cause of morbidity and mortality in children, despite vaccine developments or advancements in vaccination, antibiotics, supportive treatments, and advancements in intensive care facilities. has 12 serogroups, among which A, B, C, Y, and W are responsible for the most invasive infections. Sudden onset, rapid worsening, and high contagiousness are important clinical features of meningococcal infections. Purpura fulminans, septic shock, multiple organ failure, and increased intracranial pressure also constitute life-threatening complications. Here, we present a six-month-old female patient who presented with complaints of fever, malaise, and rash and was diagnosed with meningococcal sepsis and shock based on clinical examination, laboratory findings, and blood polymerase chain reaction (PCR) positivity. She was treated in the pediatric intensive care unit (PICU) but died despite the treatments.

摘要

尽管在疫苗研发、疫苗接种、抗生素、支持治疗以及重症监护设施方面取得了进展,但脑膜炎球菌感染仍是儿童发病和死亡的一个严重原因。脑膜炎球菌有12个血清群,其中A、B、C、Y和W群是导致侵袭性感染最多的菌群。突然发病、病情迅速恶化和高传染性是脑膜炎球菌感染的重要临床特征。暴发性紫癜、感染性休克、多器官功能衰竭和颅内压升高也构成危及生命的并发症。在此,我们报告一名6个月大的女性患者,她因发热、不适和皮疹就诊,根据临床检查、实验室检查结果及血液聚合酶链反应(PCR)阳性结果被诊断为脑膜炎球菌败血症和休克。她在儿科重症监护病房(PICU)接受治疗,但尽管进行了治疗仍死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9db/12427136/38f88e3939eb/cureus-0017-00000089950-i01.jpg

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