Troupi Maria, Daskalopoulou Dimitra, Shehade Ameer, Kiknadze Theona, Oikonomidi Chrysovalanti, Chrysikos Dimosthenis, Troupis Theodore
Department of Anatomy, National and Kapodistrian University of Athens School of Medicine, Athens, GRC.
Plastic and Reconstructive Surgery, Naval Hospital of Athens, Athens, GRC.
Cureus. 2025 Aug 12;17(8):e89941. doi: 10.7759/cureus.89941. eCollection 2025 Aug.
Nevus sebaceous of Jadassohn (NSJ) is a cutaneous benign hamartoma that has been associated with the development of malignant cutaneous tumors such as basal cell carcinoma (BCC). Its coexistence with benign cutaneous tumors has also been reported, while differential diagnosis is considered challenging due to comparable characteristics. Syringocystadenoma papilliferum (SCAP) is a rare benign adnexal tumor and its coexistence with NSJ constitutes an unusual entity, which may lead to diagnostic uncertainty and warrants histopathological examination due to potential malignant transformation. We report a case of a syringocystadenoma papilliferum in a 42-year-old female which developed over a longstanding nevus sebaceous of Jadassohn, presenting as an ulcerated nodule encircled by a hairless plaque on the scalp, a clinical association that presents diagnostic challenges and can resemble malignant skin tumors. Herein, this case highlights the importance of clinical suspicion and complete surgical excision as well as histopathological evaluation of evolving lesions to establish diagnosis and prevent the development of malignant neoplasms.
Jadassohn皮脂腺痣（NSJ）是一种皮肤良性错构瘤，与基底细胞癌（BCC）等恶性皮肤肿瘤的发生有关。其与良性皮肤肿瘤并存的情况也有报道，而由于特征相似，鉴别诊断颇具挑战性。乳头状汗管囊腺瘤（SCAP）是一种罕见的良性附属器肿瘤，它与NSJ并存构成一种不寻常的情况，这可能导致诊断不确定性，且因其有潜在恶变可能，故需进行组织病理学检查。我们报告一例42岁女性的乳头状汗管囊腺瘤，其发生于长期存在的Jadassohn皮脂腺痣之上，表现为头皮上一个溃疡结节，周围环绕着无毛斑块，这种临床关联带来了诊断挑战，且可能类似恶性皮肤肿瘤。在此，该病例强调了临床怀疑、完整手术切除以及对病变进展进行组织病理学评估以确立诊断并预防恶性肿瘤发生的重要性。
