Mayrovitz Harvey N
Medical Education, Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Davie, USA.
Cureus. 2025 Aug 12;17(8):e89919. doi: 10.7759/cureus.89919. eCollection 2025 Aug.
The term "flowmotion" describes the temporally dynamic changes in microvascular blood flow or blood velocity accompanying spontaneous time-varying changes in arteriole diameters, a process termed "vasomotion." Flowmotion is readily measurable in human skin using laser Doppler flowmetry and has been studied empirically to characterize its spectral features and disease-related changes in amplitude and frequency. However, there is a lack of clarity regarding the effect on blood flow within arterioles that exhibit these time-varying diameter changes. Thus, the goals of the present study were to (1) investigate the effects of vasomotion on blood flow within arterioles using simulated sinusoidal and trapezoidal vasomotion patterns and (2) determine the difference in blood flow effects between these two vasomotion patterns. Methods: The sinusoidal diameter was expressed as [Formula: see text] where [Formula: see text] is the peak-to-peak vasomotion amplitude and [Formula: see text] is the period of oscillation. For the trapezoidal case, the diameter was expressed in terms of the Fourier series for a periodic trapezoidal waveform. The impacts of vasomotion as a function of the amplitude a were determined analytically for the sinusoidal case and numerically for both cases.
Analysis indicates that sinusoidal and trapezoidal vasomotion are associated with an average blood flow that is greater than would be present in a vessel with a fixed diameter, and the trapezoidal pattern yields a greater increase than the sinusoidal pattern.
Analytic and numerical evaluations of sinusoidal and trapezoidal diameter variations revealed that the resultant flowmotion was associated with greater average blood flow, with the trapezoidal pattern being slightly more effective than the sinusoidal pattern. Although the impact of these dynamics on the functional aspects of the overall microvascular network, including microvascular exchange processes, was not considered in the present report, these aspects represent areas well warranted for future research.
术语“血流运动”描述了伴随小动脉直径的自发时变变化而发生的微血管血流或血流速度的时间动态变化，这一过程称为“血管运动”。使用激光多普勒血流仪可在人体皮肤中轻松测量血流运动，并已通过实验研究来表征其频谱特征以及与疾病相关的幅度和频率变化。然而，对于表现出这些时变直径变化的小动脉内血流的影响尚不清楚。因此，本研究的目的是：（1）使用模拟的正弦和梯形血管运动模式研究血管运动对小动脉内血流的影响；（2）确定这两种血管运动模式之间血流影响的差异。方法：正弦直径表示为[公式：见正文]，其中[公式：见正文]是峰峰值血管运动幅度，[公式：见正文]是振荡周期。对于梯形情况，直径用周期性梯形波形的傅里叶级数表示。对于正弦情况，通过解析确定血管运动作为幅度a的函数的影响，对于两种情况均通过数值确定。
分析表明，正弦和梯形血管运动与平均血流相关，该平均血流大于直径固定的血管中的血流，并且梯形模式比正弦模式产生更大的增加。
对正弦和梯形直径变化的解析和数值评估表明，产生的血流运动与更大的平均血流相关，梯形模式比正弦模式略有效。尽管本报告未考虑这些动态对整个微血管网络功能方面（包括微血管交换过程）的影响，但这些方面是未来研究很有必要开展的领域。
