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蒸汽辅助呼吸肌训练对男性和女性睡眠呼吸暂停症状及肺功能的影响:一项初步研究。

Effects of steam-assisted respiratory muscle training on sleep apnoea symptoms and pulmonary function in men and women: a pilot study.

作者信息

Al-Rammahi U, Soukka T, Malinen J, Happonen R P, Sovijärvi A, Anttalainen U

机构信息

Division of Surgery and Cancer Diseases, Department of Oral and Maxillofacial Surgery, Turku University Hospital, Turku, Finland.

Sleep Research Center, Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.

出版信息

Sleep Breath. 2025 Sep 15;29(5):286. doi: 10.1007/s11325-025-03449-2.

Abstract

PURPOSE

Obstructive sleep apnoea (OSA) negatively impacts quality of life and increases cardiovascular and metabolic risks. Although continuous positive airway pressure is the gold-standard treatment, limited adherence reduces its clinical effectiveness. This study investigates whether steam-assisted respiratory muscle training (RMT) can alleviate symptoms, improve pulmonary function, and explore potential differences in response between men and women with OSA.

METHODS

This open-label, 12-week prospective pilot study included 60 participants with mild to moderate OSA, who performed individualized inspiratory and expiratory counter-pressure breathing exercises with steam inhalation. Pulmonary function tests, sleep-related questionnaires, and general health assessments were conducted at baseline and post-intervention. Participants showing notable improvements from baseline were classified as high responders, enabling subgroup analyses.

RESULTS

Final results of 33 of the 60 participants showed significant mean improvements, with the Insomnia Severity Index (ISI) decreasing by 1.8 points, the Pittsburgh Sleep Quality Index (PSQI) by 2 points, and the 12-item General Health Questionnaire (GHQ-12) by 7.9 points (all p < 0.01). Forced expiratory volume in one second (FEV₁) increased from from 3.6 L to 3.8 L (p = 0.04). Subgroup analysis revealed an enhancement in sleep-related symptoms and pulmonary function.

CONCLUSIONS

RMT may serve as a patient-centered alternative for managing the symptomatic burden of mild to moderate OSA. While larger trials are needed to confirm these preliminary findings, these pilot results do not yet demonstrate sustained benefit and should be interpreted with caution. Trial registration ClinicalTrials.gov, register no. NCT05320952.

摘要

目的

阻塞性睡眠呼吸暂停(OSA)对生活质量产生负面影响,并增加心血管和代谢风险。尽管持续气道正压通气是金标准治疗方法,但依从性有限降低了其临床疗效。本研究调查蒸汽辅助呼吸肌训练(RMT)是否能缓解症状、改善肺功能,并探讨OSA男性和女性在反应上的潜在差异。

方法

这项开放标签、为期12周的前瞻性试点研究纳入了60名轻度至中度OSA患者,他们进行了个体化的吸气和呼气反压呼吸练习并吸入蒸汽。在基线和干预后进行肺功能测试、睡眠相关问卷调查和一般健康评估。与基线相比有显著改善的参与者被归类为高反应者,从而进行亚组分析。

结果

60名参与者中的33名的最终结果显示平均有显著改善,失眠严重程度指数(ISI)下降1.8分,匹兹堡睡眠质量指数(PSQI)下降2分,12项一般健康问卷(GHQ - 12)下降7.9分(均p < 0.01)。一秒用力呼气量(FEV₁)从3.6升增加到3.8升(p = 0.04)。亚组分析显示睡眠相关症状和肺功能有所改善。

结论

RMT可能作为一种以患者为中心的替代方法来管理轻度至中度OSA的症状负担。虽然需要更大规模的试验来证实这些初步发现,但这些试点结果尚未证明有持续的益处,应谨慎解读。试验注册ClinicalTrials.gov,注册号NCT05320952。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff87/12436549/c94d12cccd80/11325_2025_3449_Fig1_HTML.jpg

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