Institute of Pneumology at the University of Cologne, Clinic for Pneumology and Allergology, Center of Sleep Medicine and Respiratory Care, Bethanien Hospital, Aufderhoeherstraße 169-175, 42699, Solingen, Germany.
Krankenhaus der Augustinerinnen, Jakobstraße 27, 50678, Cologne, Germany.
Sleep Breath. 2018 May;22(2):323-328. doi: 10.1007/s11325-017-1582-6. Epub 2017 Oct 28.
Different forms of training focusing on the muscles of the upper airways showed limited effects on obstructive sleep apnea (OSA) and/or snoring. We investigated the effect of generalized respiratory muscle training (RMT) in lean patients with mild to moderate OSA.
Nine male subjects (52.0 ± 10.8 years, BMI 29.1 ± 2.1 kg/m) with obstructive sleep apnea (apnea-hypopnea index (AHI) 9-29) participated in an open, single-arm pilot study. After a 1-week build-up phase, patients underwent 4 weeks of normocapnic hyperpnea RMT five times a week for 30 min each. The initial and final measurements comprised polysomnography, pulmonary function tests, Epworth sleepiness scale (ESS), and SF-36 questionnaire (quality of life (QoL) self-assessment). The investigational site was a university-affiliated hospital for pulmonary diseases and sleep medicine, Solingen/Germany.
Patients trained effectively, seen by a significant (p < 0.01) increase of breathing frequency (23.3 ± 1.5 /min vs. 30.6 ± 2.9 /min) and minute volume (81.2 ± 13.7 L vs. 109.1 ± 21.9 L). AHI, snoring and ESS remained unchanged after training. QoL as measured by SF-36 significantly (p < 0.05) improved after the training in the subscales "bodily pain" (79 ± 21 vs. 90 ± 12) and "change of health" (3.1 ± 0.3 vs. 2.4 ± 0.5).
There is no evidence that AHI, pulmonary function or daytime sleepiness are affected by 5 weeks of RMT. Nevertheless, there is an improvement of parameters of quality of life.
ClinicalTrials.gov , register no. NCT 00936286.
针对上气道肌肉的不同形式的训练对阻塞性睡眠呼吸暂停（OSA）和/或打鼾的影响有限。我们研究了在轻度至中度 OSA 的瘦型患者中进行全身呼吸肌训练（RMT）的效果。
9 名男性受试者（52.0±10.8 岁，BMI 29.1±2.1kg/m）患有阻塞性睡眠呼吸暂停（呼吸暂停低通气指数（AHI）9-29）参加了一项开放的、单臂的试验研究。在 1 周的建立阶段后，患者每周进行 5 次、每次 30 分钟的常压高碳酸血症呼吸 RMT，共 4 周。初始和最终测量包括多导睡眠图、肺功能测试、Epworth 嗜睡量表（ESS）和 SF-36 问卷（生活质量（QoL）自我评估）。研究地点是德国索林根的一家大学附属的肺病和睡眠医学医院。
患者进行了有效的训练，呼吸频率（23.3±1.5/min 与 30.6±2.9/min）和分钟通气量（81.2±13.7L 与 109.1±21.9L）显著增加（p<0.01）。训练后 AHI、打鼾和 ESS 保持不变。SF-36 测量的 QoL 在训练后在“身体疼痛”（79±21 与 90±12）和“健康变化”（3.1±0.3 与 2.4±0.5）亚量表方面显著改善（p<0.05）。
没有证据表明 5 周的 RMT 会影响 AHI、肺功能或白天嗜睡。然而，生活质量的参数有所改善。
ClinicalTrials.gov，注册号 NCT 00936286。
