Jiang Wen, Wang Mengru, Yang Wenbo, Yao Xiaoguang, Li Nanfang
Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region "Hypertension Research Laboratory, Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, 830001, China.
Int Urol Nephrol. 2025 Sep 11. doi: 10.1007/s11255-025-04756-z.
Aldosterone plays a key role in kidney disease, but previous bibliometric studies have focused only broadly on the renin-angiotensin-aldosterone system (RAAS) or chronic kidney disease (CKD) as a whole. A focused bibliometric analysis specifically on aldosterone and kidney disease prognosis has been lacking. This study addresses that gap by mapping global research trends, identifying leading contributors, and pinpointing current priorities in this field.
We searched the Web of Science Core Collection for studies published between January 1, 1963, and May 6, 2025. Using VOSviewer, CiteSpace, and the R package "bibliometrix," we analyzed collaboration networks, author and institutional productivity, journal impact, keyword co-occurrence, and research trends.
A total of 1338 articles from 5628 institutions in 77 countries were included. The United States led in publication output and collaboration, with China and Japan following. Harvard University, INSERM, and Harvard Medical Affiliates were the most productive institutions. The most influential authors were Pitt Bertram, Zannad Faiez, and Rossignol Patrick. Top journals included Kidney International and the American Journal of Kidney Diseases. Common keywords were "mortality," "risk," "blood pressure," "aldosterone," and "chronic kidney disease." Recent research has focused on "management," "serum potassium," "mineralocorticoid receptor antagonists," and "meta-analysis," reflecting shifts toward optimizing therapy and improving safety.
This targeted bibliometric analysis fills a specific gap by clarifying how aldosterone research shapes our understanding of kidney disease prognosis. The findings highlight the need for more integrated, multidisciplinary approaches and support continued clinical and translational research to refine therapies and improve patient outcomes.
醛固酮在肾脏疾病中起关键作用，但以往的文献计量学研究仅广泛关注肾素 - 血管紧张素 - 醛固酮系统（RAAS）或整体慢性肾脏病（CKD）。专门针对醛固酮与肾脏疾病预后的文献计量学分析一直缺乏。本研究通过绘制全球研究趋势、确定主要贡献者以及明确该领域当前的优先事项来填补这一空白。
我们在科学网核心合集数据库中检索了1963年1月1日至2025年5月6日发表的研究。使用VOSviewer、CiteSpace和R包“bibliometrix”，我们分析了合作网络、作者和机构的生产力、期刊影响力、关键词共现情况以及研究趋势。
共纳入了来自77个国家5628个机构的1338篇文章。美国在发表量和合作方面领先，中国和日本紧随其后。哈佛大学、法国国家健康与医学研究院（INSERM）和哈佛医学附属机构是生产力最高的机构。最具影响力的作者是皮特·伯特伦、法耶兹·赞纳德和帕特里克·罗西尼奥尔。顶级期刊包括《国际肾脏病杂志》和《美国肾脏病杂志》。常见关键词有“死亡率”“风险”“血压”“醛固酮”和“慢性肾脏病”。近期研究集中在“管理”“血清钾”“盐皮质激素受体拮抗剂”和“荟萃分析”，这反映了研究方向朝着优化治疗和提高安全性的转变。
这项有针对性的文献计量学分析通过阐明醛固酮研究如何塑造我们对肾脏疾病预后的理解，填补了特定空白。研究结果强调需要更多综合、多学科的方法，并支持持续的临床和转化研究以优化治疗并改善患者结局。
