Talebi Marjan, Sadoughi Mohammad Mehdi, Ayatollahi Seyed Abdulmajid, Ainy Elaheh, Kiani Roghayeh, Zali Alireza, Miri MirMohammad
Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Biomed Pharmacother. 2023 Oct 28;168:115805. doi: 10.1016/j.biopha.2023.115805.
Cannabidiol (CBD), a cannabinoid that does not create psychoactive activities, has been identified as having a multitude of therapeutic benefits. This study delves into the chemical properties, pharmacokinetics, safety and toxicity, pharmacological effects, and most importantly, the association between the therapeutic potential of CBD and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. The relationship between Nrf2 and CBD is closely linked to certain proteins that are associated with cardiovascular dysfunctions, cancers, and neurodegenerative conditions. Specifically, Nrf2 is connected to the initiation and progression of diverse health issues, including nephrotoxicity, bladder-related diseases, oral mucositis, cancers, obesity, myocardial injury and angiogenesis, skin-related inflammations, psychotic disorders, neuropathic pain, Huntington's disease, Alzheimer's disease, Parkinson's disease, neuroinflammation, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis. The association between CBD and Nrf2 is a zone of great interest in the medical field, as it has the potential to significantly impact the treatment and prevention of wide-ranging health conditions. Additional investigation is necessary to entirely apprehend the mechanisms underlying this crucial interplay and to develop effective therapeutic interventions.
大麻二酚（CBD）是一种不会产生精神活性的大麻素，已被证实具有多种治疗益处。本研究深入探讨了CBD的化学性质、药代动力学、安全性与毒性、药理作用，以及最重要的，CBD的治疗潜力与核因子红细胞2相关因子2（Nrf2）信号通路之间的关联。Nrf2与CBD之间的关系与某些与心血管功能障碍、癌症和神经退行性疾病相关的蛋白质密切相关。具体而言，Nrf2与多种健康问题的发生和发展有关，包括肾毒性、膀胱相关疾病、口腔黏膜炎、癌症、肥胖、心肌损伤和血管生成、皮肤相关炎症、精神障碍、神经性疼痛、亨廷顿舞蹈症、阿尔茨海默病、帕金森病、神经炎症、肌萎缩侧索硬化症和多发性硬化症。CBD与Nrf2之间的关联是医学领域一个备受关注的领域，因为它有可能对广泛的健康状况的治疗和预防产生重大影响。需要进一步研究以全面理解这种关键相互作用的潜在机制，并开发有效的治疗干预措施。
