Tharmarajah Shenthuraan, Abideen Zain, Hussain Swaleh, Guilcher Sara J T, McCarthy Lisa M, Mahendira Dharini, Berger Howard, Tadrous Mina
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
ICES, Toronto, Ontario, Canada.
PLoS One. 2025 Sep 15;20(9):e0332374. doi: 10.1371/journal.pone.0332374. eCollection 2025.
Despite increasing rheumatic disease prevalence among female individuals in Ontario, Canada, research is limited on whether this has translated to an increased proportion of pregnancies with rheumatic diseases. This study aimed to assess rheumatic disease rates among pregnant individuals in Ontario, Canada.
Using healthcare administrative claims databases from ICES, the proportion of pregnancies with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) from April 2011 to March 2021 were examined. The Mann-Kendall rank correlation test was used to test for trends in overall and individual rheumatic disease rates across the study period.
In total, 1,408,100 pregnancies were recorded from fiscal years 2011-2020 in Ontario. Of these, 4,392 involved patients with rheumatic diseases. The overall rheumatic disease rate among pregnant individuals increased by 24% from 28.3 to 35.2 pregnancies per 10,000 over the study period (p = 0.0157). RA rates increased 22% from 11.1 to 13.5 per 10,000 (p = 0.0056), while PsA rates increased 111% from 0.9 to 1.9 per 10,000 (p = 0.0157). SLE, AS, and multiple rheumatic disease rates did not increase significantly.
The proportion of individuals with rheumatic diseases pursuing pregnancy in Ontario has increased, perhaps aided by advancements in disease diagnostics and treatment strategies. Further research is needed to link antirheumatic drug safety to pregnancy outcomes and explore other factors that may influence pregnancy rates among this patient population.
尽管加拿大安大略省女性风湿性疾病患病率不断上升，但关于这是否导致患风湿性疾病的孕妇比例增加的研究有限。本研究旨在评估加拿大安大略省孕妇的风湿性疾病发病率。
利用ICES的医疗保健行政索赔数据库，调查了2011年4月至2021年3月期间患有类风湿性关节炎（RA）、系统性红斑狼疮（SLE）、银屑病关节炎（PsA）和强直性脊柱炎（AS）的孕妇比例。采用曼-肯德尔秩相关检验来检验研究期间总体和个别风湿性疾病发病率的趋势。
2011 - 2020财年安大略省共记录了1,408,100例妊娠。其中，4392例涉及患有风湿性疾病的患者。在研究期间，孕妇的总体风湿性疾病发病率从每10,000例28.3例增加到35.2例，增长了24%（p = 0.0157）。RA发病率从每10,000例11.1例增加到13.5例，增长了22%（p = 0.0056），而PsA发病率从每10,000例0.9例增加到1.9例，增长了111%（p = 0.0157）。SLE、AS和多种风湿性疾病的发病率没有显著增加。
安大略省患有风湿性疾病且怀孕的人数比例有所增加，这可能得益于疾病诊断和治疗策略的进步。需要进一步研究将抗风湿药物安全性与妊娠结局联系起来，并探索可能影响该患者群体妊娠率的其他因素。
