Jacobsson M, Jönsson A, Albrektsson T, Turesson I
Scand J Plast Reconstr Surg. 1985;19(3):231-6. doi: 10.3109/02844318509074508.
In the present study the influence of single 2.5 and 5 Gy doses of irradiation on the regenerative capacity of mature bone tissue has been investigated. To the knowledge of the present authors, no quantitative analysis of bone repair after low doses of irradiation has been presented previously. The experimental model used was the Bone Growth Chamber (BGC), which is a porous implant made of titanium. Each one of twenty animals was irradiated with 2.5 or 5 Gy to one tibial metaphysis. Directly after irradiation each animal had BGC:s inserted bilaterally into the tibial metaphyses. Thus, each animal served as its own control. Four weeks after irradiation the BGC:s were removed and the newly formed bone was collected from the implant pores and was analyzed by microradiography and quantified by microdensitometry and histology. It was found that 2.5 Gy irradiation led to no statistically significant alteration in bone formation as compared to non-irradiated controls. At the 5 Gy dose level, however, there was a significant reduction of bone formation as compared to non-irradiated controls.
在本研究中，已对单次2.5 Gy和5 Gy剂量的辐射对成熟骨组织再生能力的影响进行了研究。就本研究作者所知，此前尚未有关于低剂量辐射后骨修复的定量分析报道。所使用的实验模型是骨生长室（BGC），它是一种由钛制成的多孔植入物。二十只动物中的每一只都对一侧胫骨干骺端进行2.5 Gy或5 Gy的辐射。辐射后立即将BGC双侧插入每只动物的胫骨干骺端。因此，每只动物自身作为对照。辐射四周后取出BGC，从植入物孔隙中收集新形成的骨，并通过显微放射摄影进行分析，通过显微密度测定法和组织学进行定量。结果发现，与未辐射的对照组相比，2.5 Gy辐射导致骨形成无统计学上的显著改变。然而，在5 Gy剂量水平下，与未辐射的对照组相比，骨形成显著减少。
